PGGT1B - protein geranylgeranyltransferase type I subunit beta Gene

Also Known as BGGI; GGTI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5229

About PGGT1B

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,204,012-115,262,877 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 3.0), spleen (RPKM 2.3) and 25 other tissues.

Summary

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]

PGGT1B Products (1)

mRNA Protein Name
NM_005023.4 NP_005014.2 geranylgeranyl transferase type-1 subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
24981860 GOA
enables protein geranylgeranyltransferase activity IDA
IDA: Inferred from direct assay
16893176 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in protein geranylgeranylation IDA
IDA: Inferred from direct assay
16893176 GOA
Cellular Component GO Annotation Evidence Referencias Source
part of CAAX-protein geranylgeranyltransferase complex IDA
IDA: Inferred from direct assay
16893176 GOA
part of CAAX-protein geranylgeranyltransferase complex IPI
IPI: Inferred from physical interaction
8106351 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGGT1B Protein Structure

SQHop_cyclase_N

SQHop_cyclase_N: Squalene-hopene cyclase N-terminal domain (119 - 209)

Prenyltrans

Prenyltrans: Prenyltransferase and squalene oxidase repeat (244 - 283)

Prenyltrans

Prenyltrans: Prenyltransferase and squalene oxidase repeat (290 - 332)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

geranylgeranyl transferase type-1 subunit beta

  • CTC-428G20.3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS10383 PGGT1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21169 Pggt1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27686 Pggt1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PGGT1B VGNC VGNC:32788
Canis familiaris PGGT1B VGNC VGNC:44459
Mus musculus PGGT1B MGD MGI:1917514
Felis catus PGGT1B VGNC VGNC:68814
Macaca mulatta PGGT1B VGNC VGNC:75965
Rattus norvegicus PGGT1B RGD RGD:621754
Others PGGT1B NCBI