Pdzk1 - PDZ domain containing 1 Gene

Also Known as Pdzd1; Nherf3; mPDZK1; NHERF-3; naPi-Cap1; D3Ertd537e; 1700023D20Rik; 2610507N21Rik; 4921513F16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59020

Summary

Predicted to enable PDZ domain binding activity; protein-membrane adaptor activity; and scavenger receptor binding activity. Involved in positive regulation of protein targeting to membrane; protein localization to plasma membrane; and regulation of anion transport. Acts upstream of or within in utero embryonic development. Located in brush border membrane. Is expressed in several structures, including genitourinary system; liver; trunk; and white fat. Orthologous to human PDZK1 (PDZ domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdzk1 Products (3)

mRNA Protein Name
NM_001146001.2 NP_001139473.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF3
NM_001355710.1 NP_001342639.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF3
NM_021517.3 NP_067492.2 Na(+)/H(+) exchange regulatory cofactor NHE-RF3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
14531806 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
27996060 MGI
involved in positive regulation of protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
16141316 MGI
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
17990980 MGI
involved in regulation of monoatomic anion transport IMP
IMP: Inferred from mutant phenotype
16141316 MGI
Cellular Component GO Annotation Evidence Referencias Source
located in brush border membrane IDA
IDA: Inferred from direct assay
15523054 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16141316 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF3

  • CFTR-associated protein of 70 kDa

  • Na(+)/H(+) exchanger regulatory factor 3

  • PDZ domain-containing protein 1

  • na/Pi cotransporter C-terminal-associated protein 1

  • sodium-hydrogen exchanger regulatory factor 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS10305 PDZK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10306 PDZK1IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20077 Pdzk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21275 Pdzk1ip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26580 Pdzk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27794 Pdzk1ip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdzk1 NCBI NCBI:5174