SFRP2 - secreted frizzled related protein 2 Gene

Also Known as FRP-2; SARP1; SDF-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6423

About SFRP2

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:153,780,591-153,789,083 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 15 paralogues. Biased expression in urinary bladder (RPKM 276.9), gall bladder (RPKM 211.4) and 9 other tissues.

Summary

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal Cancer. [provided by RefSeq, Jul 2008]

SFRP2 Products (1)

mRNA Protein Name
NM_003013.3 NP_003004.1 secreted frizzled-related protein 2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Referencias Source
involved in cardiac left ventricle morphogenesis IMP
IMP: Inferred from mutant phenotype
19593212 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19095296 GOA
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
20208569 GOA
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17471511 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
20208569 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
20208569 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17848950 GOA
involved in negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
19095296 GOA
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
19095296 GOA
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19593212 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17848950 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10980594 GOA
acts upstream of or within positive regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
12055200 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in extracellular space IDA
IDA: Inferred from direct assay
10980594 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFRP2 Protein Structure

Fz

Fz: Fz domain (40 - 153)

NTR

NTR: UNC-6/NTR/C345C module (188 - 287)

  • 0
  • 100
  • 200
  • 295 a.a.
Protein Preferred Names Protein Names

secreted frizzled-related protein 2

  • SARP-1

Recombinant SFRP2 Proteins

Referencia número Nombre del producto Accession Pureza
HY-P77835 SFRP2 Protein, Human (HEK293, His, solution) Q96HF1 (L25-C295) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Esophageal Basaloid Squamous Cell Carcinoma

  • Basaloid Squamous Carcinoma Of Esophagus

  • Esophageal Basaloid Carcinoma
Retinal Degeneration

  • Degeneration Of Retina
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Colorectal Adenoma

  • Colorectal Adenomas

  • Adenoma Of Large Intestine
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS12775 SFRP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17992 Sfrp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24463 Sfrp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SFRP2 VGNC VGNC:77186
Mus musculus SFRP2 MGD MGI:108078
Felis catus SFRP2 VGNC VGNC:107462
Bos taurus SFRP2 VGNC VGNC:34521
Rattus norvegicus SFRP2 RGD RGD:735163
Canis familiaris SFRP2 VGNC VGNC:46081
Others SFRP2 NCBI