CHMP6 - charged multivesicular body protein 6 Gene

Also Known as VPS20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79643

About CHMP6

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:80,991,841-81,000,133 (from NCBI)

This gene has 4 transcripts (splice variants) and 259 orthologues. Ubiquitous expression in kidney (RPKM 3.0), colon (RPKM 3.0) and 25 other tissues.

Summary

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012]

CHMP6 Products (1)

mRNA	Protein	Name
NM_024591.5	NP_078867.2	charged multivesicular body protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14505570	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16973552	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	16554368	GOA
involved in negative regulation of epidermal growth factor-activated receptor activity	IMP IMP: Inferred from mutant phenotype	16973552	GOA
involved in nuclear membrane reassembly	IMP IMP: Inferred from mutant phenotype	26040713	GOA
involved in nucleus organization	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in plasma membrane repair	IDA IDA: Inferred from direct assay	24482116	GOA
NOT involved in regulation of exosomal secretion	IMP IMP: Inferred from mutant phenotype	22660413	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	18606141	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	17984323	GOA
involved in viral budding from plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA
involved in viral budding via host ESCRT complex	IDA IDA: Inferred from direct assay	24878737	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
part of ESCRT III complex	IDA IDA: Inferred from direct assay	24878737	GOA
located in amphisome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	16973552	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	26040712	GOA
located in kinetochore microtubule	IDA IDA: Inferred from direct assay	26040712	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in midbody	IDA IDA: Inferred from direct assay	26040712	GOA
located in multivesicular body membrane	IDA IDA: Inferred from direct assay	16554368	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	26040713	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHMP6 Protein Structure

Snf7

0
100
201 a.a.

Protein Preferred Names	Protein Names
charged multivesicular body protein 6	chromatin-modifying protein 6

CHMP6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	CHMP6	Q96FZ7	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	CHMP6	Q96FZ7	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	CHMP6	Q96FZ7	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	CHMP6	Q96FZ7	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	CHMP6	Q96FZ7	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	CHMP6	Q96FZ7	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	CHMP6	Q96FZ7	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	CHMP6	Q96FZ7	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	CHMP6	Q96FZ7	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	CHMP6	Q96FZ7	VPS25	Homo sapiens	Q9BRG1	Validated Y2H	32296183
Intra	CHMP6	Q96FZ7	VPS25	Homo sapiens	Q9BRG1	Anti Tag CoIP	33961781
Intra	CHMP6	Q96FZ7	VPS25	Homo sapiens	Q9BRG1	Pull Down	16856878

Cross: Cross-species interaction Intra: Intraspecies interaction

CHMP6 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P83695	CHMP6 Antibody	WB, IHC-P	Human, Mouse

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS02647	CHMP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHMP6	MGD	MGI:3583942
Rattus norvegicus	CHMP6	RGD	RGD:1565325
Canis familiaris	CHMP6	VGNC	VGNC:51941
Felis catus	CHMP6	VGNC	VGNC:98880
Bos taurus	CHMP6	VGNC	VGNC:27305
Macaca mulatta	CHMP6	VGNC	VGNC:71100
Others	CHMP6	NCBI