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RBP5 - retinol binding protein 5 Gene

Also Known as CRBP3; CRBPIII; HRBPiso; CRBP-III

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83758

About RBP5

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,115,736-7,130,005 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 240 orthologues and 15 paralogues. Biased expression in kidney (RPKM 131.3), liver (RPKM 58.1) and 3 other tissues.

Summary

The protein encoded by this gene is a cellular retinol-binding protein expressed highly in kidney and liver. Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates. [provided by RefSeq, Jul 2016]

RBP5 Products (2)

mRNA	Protein	Name
NM_001329454.2	NP_001316383.1	retinol-binding protein 5 isoform 2
NM_031491.4	NP_113679.1	retinol-binding protein 5 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBP5 Protein Structure

Lipocalin

0
100
135 a.a.

Protein Preferred Names	Protein Names
retinol-binding protein 5	cellular retinol-binding protein III

RBP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	RBP5	P82980	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	RBP5	P82980	AGR2	Homo sapiens	O95994	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RBP5 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P71250	RBP5 Protein, Human	P82980 (M1-R135)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Total Anomalous Pulmonary Venous Return 1	Scimitar Syndrome Total Anomalous Pulmonary Venous Return Anomalous Pulmonary Venous Return Scimitar Anomaly TAPVR1 Apvr Halasz Syndrome Hypogenetic Lung Syndrome Pulmonary Venolobar Syndrome TAPVR Congenital Total Pulmonary Venous Return Anomaly Congenital Venolobar Syndrome Mirror-Image Lung Syndrome Vena Cava Bronchovascular Syndrome Pulmonary Venous Return Anomaly Congenital Pulmonary Venolobar Syndrome Epibronchial Right Pulmonary Vein Syndrome
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS03134	CRABP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11770	RBP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18859	Crabp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown