DCTN5 - dynactin subunit 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84516

About DCTN5

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,641,466-23,677,472 (from NCBI)

This gene has 8 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in brain (RPKM 13.0), testis (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

DCTN5 Products (3)

mRNA Protein Name
NM_001199011.2 NP_001185940.1 dynactin subunit 5 isoform 2
NM_001199743.2 NP_001186672.1 dynactin subunit 5 isoform 3
NM_032486.4 NP_115875.1 dynactin subunit 5 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCTN5 Protein Structure

Hexapep

Hexapep: Bacterial transferase hexapeptide (six repeats) (101 - 128)

  • 0
  • 100
  • 182 a.a.
Protein Preferred Names Protein Names

dynactin subunit 5

  • dynactin 4

DCTN5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
DCTN5 Q9BTE1 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
Intra
DCTN5 Q9BTE1 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
Intra
DCTN5 Q9BTE1 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra
DCTN5 Q9BTE1 RBPMS Homo sapiens Q93062
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

DCTN5 Antibodies

Referencia número Nombre del producto Aplicación Reactivity
HY-P82245 Dynactin Subunit 5 Antibody (YA1990) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Autosomal Dominant Nonsyndromic Deafness 77

  • Dfna77
Charcot-Marie-Tooth Disease, Axonal, Type 2o

  • Charcot-Marie-Tooth Disease Axonal Type 2o

  • CMT2O

  • Autosomal Dominant Charcot-Marie-Tooth Disease Type 2o

  • Charcot-Marie-Tooth Neuropathy Axonal Type 2o

  • Charcot-Marie-Tooth Neuropathy, Axonal, Type 2o

  • Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2o

  • Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2o

  • Charcot-Marie-Tooth Disease 2o

  • Charcot-Marie-Tooth Disease Axonal Autosomal Dominant Type 2o
Joubert Syndrome 17

  • JBTS17

  • Joubert Syndrome, Type 17
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS03596 DCTN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DCTN5 VGNC VGNC:61381
Macaca mulatta DCTN5 VGNC VGNC:71703
Bos taurus DCTN5 VGNC VGNC:27932
Canis familiaris DCTN5 VGNC VGNC:39820
Rattus norvegicus DCTN5 RGD RGD:1305654
Mus musculus DCTN5 MGD MGI:1891689
Others DCTN5 NCBI