CAV2 - caveolin 2 Gene

Also Known as CAV

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 858

About CAV2

Cytogenetic location: 7q31.2 Genomic coordinates (GRCh38): 7:116,499,738-116,508,541 (from NCBI)

This gene has 15 transcripts (splice variants), 194 orthologues and 2 paralogues. Broad expression in fat (RPKM 133.6), lung (RPKM 106.3) and 17 other tissues.

Summary

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and Apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each Other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]

CAV2 Products (4)

mRNA	Protein	Name
NM_001206747.2	NP_001193676.1	caveolin-2 isoform b
NM_001206748.2	NP_001193677.1	caveolin-2 isoform d
NM_001233.5	NP_001224.1	caveolin-2 isoform a
NM_198212.3	NP_937855.1	caveolin-2 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	15569306	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10212252	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	8552590	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in caveola assembly	IDA IDA: Inferred from direct assay	12743374	GOA
involved in caveola assembly	IMP IMP: Inferred from mutant phenotype	12633858	GOA
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	20455999	GOA
involved in positive regulation by host of viral process	IMP IMP: Inferred from mutant phenotype	25556234	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	8552590	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	20455999	GOA
involved in positive regulation of dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15569306	GOA
involved in receptor-mediated endocytosis of virus by host cell	IGI IGI: Inferred from genetic interaction	21047970	GOA
involved in regulation of mitotic nuclear division	IEP IEP: Inferred from expression pattern	18081315	GOA
involved in vesicle docking	IDA IDA: Inferred from direct assay	12743374	GOA
involved in vesicle fusion	IDA IDA: Inferred from direct assay	12743374	GOA
involved in vesicle organization	IDA IDA: Inferred from direct assay	12743374	GOA
involved in viral release from host cell	IMP IMP: Inferred from mutant phenotype	25556234	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in caveola	IDA IDA: Inferred from direct assay	8552590	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	22792322	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	12091389	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	11294831	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18081315	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8552590	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	15569306	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	24013648	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAV2 Protein Structure

Caveolin

0
100
162 a.a.

Protein Preferred Names	Protein Names
caveolin-2	caveolae protein, 20-kD

CAV2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	CAV2	P51636	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	CAV2	P51636	CAV1	Homo sapiens	Q03135	Anti Tag CoIP	31980649

Cross: Cross-species interaction Intra: Intraspecies interaction

CAV2 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P82642	Caveolin 2 Antibody (YA2387)	WB, IHC-P, ICC/IF, FC	Human
HY-P82642A	Caveolin 2 Antibody (YA2387)(PBS only)	WB, IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Lung Pleomorphic Carcinoma
Episodic Ataxia, Type 2	Episodic Ataxia Type 2 EA2 Apca Capa Cerebellopathy, Hereditary Paroxysmal Acetazolamide-Responsive Hereditary Paroxysmal Cerebellar Ataxia Cerebellar Ataxia, Paroxysmal, Acetazolamide-Responsive Episodic Ataxia With Nystagmus Ataxia, Episodic, With Nystagmus Episodic Ataxia, Nystagmus-Associated Ataxia, Familial Paroxysmal Acetazolamide-Responsive Episodic Ataxia Syndrome Acetazolamide-Responsive, Hereditary, Paroxysmal, Cerebellar Ataxia Ataxia, Familial, Paroxysmal Nystagmus-Associated Episodic Ataxia Familial Paroxysmal Ataxia Episodic Ataxia 2 Ea-2 Episodic Ataxia Nystagmus-Associated Hereditary Paroxysmal Cerebellopathy Ataxia, Episodic, Type 2
Brill-Zinsser Disease	Recrudescent Typhus Brill Disease Brill Zinsser Disease Brill'S Disease Latent Typhus Sporadic Typhus Typhus, Epidemic Louse-Borne Recrudescent Typhus Due To Rickettsia Prowazekii Recrudescent Typhus Fever Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii Recrudescent Brill Disease Recrudescent Typhus Fever Due To Rickettsia Prowazekii
Rippling Muscle Disease 2	Rippling Muscle Disease Rmd Lgmd1c RMD2 Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1c Muscular Dystrophy, Limb-Girdle, Type 1c Muscular Dystrophy, Limb-Girdle, Type 1c, Formerly Lgmd1c, Formerly Limb-Girdle Muscular Dystrophy Type 1c Limb-Girdle Muscular Dystrophy Due To Caveolin-3 Deficiency Muscular Dystrophy, Limb-Girdle, Type Ic Rippling Muscle Syndrome Limb-Girdle Muscular Dystrophy 1c Dystrophy, Muscular, Limb-Girdle, Type 1c Disease, Muscle, Rippling, Type 2 Rippling Muscle Disease 1
Queensland Tick Typhus	Australian Tick Typhus North Queensland Tick Typhus Rickettsia Australis Spotted Fever
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary
Glaucoma, Normal Tension	Low Tension Glaucoma Glaucoma, Normal Tension, Susceptibility To Normal Tension Glaucoma Ntg Glaucoma, Normal Pressure NPG Glaucoma, Normal Pressure, Susceptibility To Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]
Lipodystrophy, Congenital Generalized, Type 3	Congenital Generalized Lipodystrophy Type 3 CGL3 Bscl3 Berardinelli-Seip Congenital Lipodystrophy Type 3 Berardinelli-Seip Congenital Lipodystrophy, Type 3 Lipodystrophy, Berardinelli-Seip Congenital, Type 3 Type 3 Berardinelli-Seip Congenital Lipodystrophy Congenital Generalized Lipodystrophy 3
Spinocerebellar Ataxia 6	Spinocerebellar Ataxia Type 6 SCA6 Type 6 Spinocerebellar Ataxia Spinocerebellar Ataxia-6 Ataxia, Spinocerebellar, Type 6
Open-Angle Glaucoma	Glaucoma Simplex Pigmentary Glaucoma Wide-Angle Glaucoma Glaucoma, Open-Angle Open Angle Glaucoma Glaucoma Open-Angle Chronic Simple Glaucoma Coag - [Chronic Open-Angle Glaucoma] Csg - [Chronic Simple Glaucoma] Poag - [Primary Open-Angle Glaucoma] Oag - [Open-Angle Glaucoma] Chronic Glaucoma Chronic Open Angle Glaucoma Simple Glaucoma Chronic Noncongestive Glaucoma Ltg - [Low Tension Glaucoma] Noncongestive Glaucoma Nonobstructive Glaucoma Normal Pressure Glaucoma Primary Low Tension Glaucoma Low-Tension Glaucoma Residual Stage Low Tension Glaucoma Open Cleft Glaucoma
Isolated Elevated Serum Creatine Phosphokinase Levels	Elevated Serum Cpk Idiopathic Hyperckemia Isolated Hyperckemia Elevated Serum Creatine Phosphokinase H-Ck Idiopathic Persistent Elevation Of Serum Creatine Kinase
Episodic Ataxia	Isaacs Syndrome Neuromyotonia Isaacs' Syndrome Acquired Neuromyotonia Continuous Muscle Fiber Activity Syndrome Quantal Squander Syndrome Isaacs-Mertens Syndrome Ea Syndrome Episodic Ataxia Syndrome Isaac Syndrome Isaac'S-Merten'S Syndrome Isaac-Mertens Syndrome Peripheral Nerve Hyperexcitability Ea Peripheral Nerve Hyperexcitability Syndrome Ataxia, Episodic Isaacs Neuromyotonia Continuous Muscle Fibre Activity
Congenital Stationary Night Blindness	Night Blindness, Congenital Stationary Congenital Essential Nyctalopia Oguchi Disease Blindness, Night, Stationary, Congenital
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P1080A	ω-Agatoxin IVA TFA	Inhibitor	99.52%	Unkown
HY-P1074	SNX-482	Inhibitor	≥99.0%	Unkown
HY-119373	Cav 2.2 blocker 1	Inhibitor	98.85%	Unkown
HY-120751	TROX-1	Inhibitor	99.55%	Unkown
HY-164803	CBD3063	Modulator	99.75%	Unkown
HY-P1080	ω-Agatoxin IVA	Inhibitor	98.71%	Unkown
HY-132268	Cav 2.2 blocker 2	Inhibitor	98.51%	Unkown
HY-115597	BTT-266	Antagonist	98.90%	Unkown
HY-120751A	(S)-TROX-1	Inhibitor	99.52%	Unkown
HY-115596	BTT-369	Antagonist	/	Unkown
HY-147639	Cav 2.2/3.2 blocker 1	Inhibitor	/	Unkown
HY-148866	Cavα2δ1&NET-IN-3	Inhibitor	/	Unkown
HY-169845	Calcium Channel antagonist 6	Antagonist	/	Unkown
HY-180400	PAM-2		/	Unkown
HY-181612	COX-2/CaV2.2-IN-1	Inhibitor	/	Unkown
HY-181957	KB528		/	Unkown
HY-P10898	GeX-2		/	Unkown
HY-P5813	Cd1a	Inhibitor	/	Unkown
HY-P5874	Myr-TAT-CBD3	Inhibitor	/	Unkown
HY-RS01987	CAV2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N12768	Rhodojaponin VI	Inhibitor	/	Unkown
HY-P3269	Calciseptine	Inhibitor	/	Unkown
HY-RS20256	Cav2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26764	Cav2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CAV2	RGD	RGD:620348
Canis familiaris	CAV2	VGNC	VGNC:38752
Macaca mulatta	CAV2	VGNC	VGNC:80806
Bos taurus	CAV2	VGNC	VGNC:26800
Mus musculus	CAV2	MGD	MGI:107571
Felis catus	CAV2	VGNC	VGNC:60399
Others	CAV2	NCBI