1. Membrane Transporter/Ion Channel
  2. Calcium Channel
  3. Cav 2.2 blocker 1

Cav 2.2 blocker 1 

Cat. No.: HY-119373 Purity: 99.30%
Handling Instructions

Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain, with an IC50 of 1 nM.

For research use only. We do not sell to patients.

Cav 2.2 blocker 1 Chemical Structure

Cav 2.2 blocker 1 Chemical Structure

CAS No. : 1567335-29-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain, with an IC50 of 1 nM[1].

IC50 & Target

IC50: 1 nM (Cav 2.2)[1].

Molecular Weight

424.96

Formula

C₂₅H₂₉ClN₂O₂

CAS No.

1567335-29-8

SMILES

COC(C=CC=C1)=C1N2C(C3=CC=C(Cl)C=C3)=CC(C4CC(C)(C)OC(C)(C)C4)=N2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (49.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3532 mL 11.7658 mL 23.5316 mL
5 mM 0.4706 mL 2.3532 mL 4.7063 mL
10 mM 0.2353 mL 1.1766 mL 2.3532 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Cav 2.2 blocker 1
Cat. No.:
HY-119373
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