2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Cav 2.2 blocker 1

Cav 2.2 blocker 1 

Cat. No.: HY-119373 Purity: 99.38%
COA Handling Instructions

Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain, with an IC50 of 1 nM.

For research use only. We do not sell to patients.

Cav 2.2 blocker 1 Chemical Structure

Cav 2.2 blocker 1 Chemical Structure

CAS No. : 1567335-29-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 385 In-stock
Solid
1 mg USD 166 In-stock
5 mg USD 350 In-stock
10 mg USD 550 In-stock
50 mg USD 1650 In-stock
100 mg USD 2650 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Cav 2.2 blocker 1 Related Antibodies

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1 Publications Citing Use of MCE Cav 2.2 blocker 1

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  • References

  • Customer Review

Description

Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain, with an IC50 of 1 nM[1].

IC50 & Target

IC50: 1 nM (Cav 2.2)[1].
Molecular Weight

424.96

Appearance

Solid

Formula

C25H29ClN2O2
CAS No.
SMILES

COC(C=CC=C1)=C1N2C(C3=CC=C(Cl)C=C3)=CC(C4CC(C)(C)OC(C)(C)C4)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (49.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3532 mL 11.7658 mL 23.5316 mL
5 mM 0.4706 mL 2.3532 mL 4.7063 mL
10 mM 0.2353 mL 1.1766 mL 2.3532 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.89 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.38%

COA (255 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References
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Cav 2.2 blocker 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Cav 2.2 blocker 11567335-29-8Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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