ODN 1018 sodium
Based on 2 publication(s) in Google Scholar
ODN 1018 (1018 ISS) sodium is a TLR9 agonist and immune modulator. ODN 1018 sodium exhibits adjuvant activity and augments CD8+ T cell responses with LNP-encapsulated OVA peptides. ODN 1018 sodium triggers sustained suppression of allergic airway inflammation. ODN 1018 sodium can be used for the research of allergic asthma and systemic lupus erythematosus.
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- Pureza: 97.49%
- Peso molecular:7150 (free acid)
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Publications Citing Use of MedChemExpress (MCE) ODN 1018 sodium
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Actividad biológica
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TLR9 |
ODN1018 (0.7 μM) sodium stimulates proliferation and IL-6 production in purified human B cells, and this stimulation is inhibited by IRS at 0.35-0.7 μM[3].
ODN1018 (0.7 μM; 48 h) sodium activates mouse splenocytes to produce IL-6 via TLR9, and this activation is dose-dependently inhibited by IRS 869 at 0.0875-0.7 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ODN 1018 (20 μg; intranasally; weekly; 1-17 weeks) sodium induces sustained suppression of allergic airway inflammation in ragweed-sensitized mice, with 5 weekly doses sufficient for durable effects associated with TReg induction[2].
ODN 1018 (50 μg; s.c.) sodium induces a lethal TLR9-mediated inflammatory response in D-galactosamine-pretreated BALB/c mice[3].
ODN 1018 (25 μg; s.c.) sodium stimulates TLR9-mediated cytokine (IL-6, IL-12) production in BALB/c mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (6-8 week old female, ragweed-sensitized allergic asthma model)[2]
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Dosage:20 μg
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Administration:intranasally; weekly; 1, 3, 5, 8, 12, 13, 16, or 17 weeks
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Result:Suppressed bronchoalveolar lavage (BAL) eosinophilia, BAL IL-4, IL-5, IL-13 levels, and lung Th2-associated genes (Il13, Ccl11, Gob5, Fizz1) through 13 subsequent weekly ragweed exposures (12 weekly treatments).
Induced significant, lasting reduction of Th2-mediated responses (5 weekly treatments); Upregulated lung regulatory T cell (TReg)-associated genes (Foxp3, Il10, Tgfb1, Lag3, Tnfrsf4, Il2ra) and increased TReg activity (CD4+CD25+ T cells from treated mice suppressed CD4+CD25- T cell proliferation more effectively than those from ragweed-only mice) (16 weekly treatments).
Induced a moderate Th1 shift (progressive increase in lung Ifng, Cxcl9, Cxcl10 expression) but Th2 suppression did not require IFN-γ; Prevented ragweed-pulsed bone marrow dendritic cells from restoring Th2 responses.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Appearance Solid
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Peso molecular 7150 (free acid)
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Color Off-white to light yellow
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SMILES
[ODN 1018 (sodium)]
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Synonyms
1018 ISS sodium
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nature
2025 May;641(8061):202-210. PMID: 40140567
ODN 1018 sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 May;641(8061):202-210. [Abstract]
Mice were immunized with ABM5-OVA, or OVA peptide with or without 10 μg of ODN1018, ISCOMs or poly-I:C on days 0 and 14.
ODN 1018 sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 May;641(8061):202-210. [Abstract]
Mice were immunized with ABM5-OVA, or OVA peptide with or without 10 μg of ODN1018, ISCOMs or poly-I:C on days 0 and 28.
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J Ethnopharmacol
Elucidating the anti-HSV-2 mechanism of Longdan Xiegan Decoction via the TLR9 signaling pathway: A multi-omics perspective. [Abstract]2026 Jun 12:364:121470. PMID: 41791624
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2242 KB)
Referencias
[1]. Friedberg JW, et al. Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma. Br J Haematol. 2009 Aug;146(3):282-91. [Content Brief]
[2]. Eng NF, et al. The potential of 1018 ISS adjuvant in hepatitis B vaccines: HEPLISAV™ review. Hum Vaccin Immunother. 2013 Aug;9(8):1661-72. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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