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Referencia número: HY-149776

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RGH-560

RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice.

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No. CAS: 2408799-43-7
Fòrmula: C₂₂H₂₀FN₃O₃
Peso molecular:393.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

RGH-560 Chemical Structure

No. CAS: 2408799-43-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Bioz

Actividad biológica

Descripciòn

In Vivo

RGH-560 (compound 53) (1 mg/kg, 3 mg/kg, 10 mg/kg; Intraperitoneal injection) has significant cognitive-enhancement in Scopolamine(HY-N0296)-induced amnesia in mice. RGH-560 is a medium clearance compound. RGH-560 is non-toxic to mice at doses up to 30 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice with scopolamine-induced amnesia^[1]
Dosage:

1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Reversed the scopolamine-induced cognitive impairment.

Chemical Information

No. CAS 2408799-43-7
Peso molecular 393.41
Fòrmula C₂₂H₂₀FN₃O₃
SMILES

CN1C=CC2=C1C=CC(CNC(N3CC4(CC(C(C=CC(F)=C5)=C5O4)=O)C3)=O)=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Ledneczki I, et al. Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560). Journal of Medicinal Chemistry. 2023 Nov. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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