25 Results for "

classical complement pathway

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "classical complement pathway" in MCE Product Catalog:

5
Tanruprubart
Tanruprubart
0 Images
5 Cited Publications
Referencia número: HY-P990545
No. CAS: 2065212-40-8
Synonyms: ANX005

Target:  

Complement System

Áreas de investigación:  

Neurological Disease

Tanruprubart (ANX005) is a C1q inhibitor and C1q depleter. Tanruprubart is a human antibody expressed in CHO cells, with huIgG1 heavy chains and huκ light chains, and its predicted molecular weight (MW) is 145 kDa. For the isotype control of Tanruprubart, refer to Human IgG1 kappa, Isotype Control (HY-P99001). The IC50 of Tanruprubart is 346 ng/mL for humans and 259 ng/mL for rats; its EC50 is 3.8 ng/mL for humans, 5.2 ng/mL for rats, and 9.9 ng/mL for mice. Tanruprubart is applicable to the research of Guillain-Barré syndrome and Alzheimer's disease .
loading...
    loading...
View All Sizes
3
Compstatin
Compstatin
0 Images
3 Cited Publications
Referencia número: HY-P1036
No. CAS: 206645-99-0
Target:  

Complement System

Áreas de investigación:  

Others

Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively .
loading...
    loading...
View All Sizes
3
Compstatin TFA
Compstatin TFA
0 Images
3 Cited Publications
Referencia número: HY-P1036A
Target:  

Complement System

Áreas de investigación:  

Others

Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibits only the activation of primates’ complement system. Compstatin TFA exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively .
loading...
    loading...
View All Sizes
1
3-Phenoxybenzaldehyde
3-Phenoxybenzaldehyde
0 Images
1 Cited Publications
Referencia número: HY-Y0641
No. CAS: 39515-51-0
Synonyms: m-Phenoxybenzaldehyde
Target:  

Complement System

Áreas de investigación:  

Inflammation/Immunology

3-Phenoxybenzaldehyde has weak complement classical pathway inhibition and hemolytic activity .
loading...
    loading...
View All Sizes
Crovalimab
Crovalimab
0 Images
Referencia número: HY-P99965
No. CAS: 1917321-26-6
Synonyms: SKY59; RO7112689; RG-6107

Target:  

Complement System

Áreas de investigación:  

Cardiovascular Disease Metabolic Disease

Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research .
loading...
    loading...
View All Sizes
C1q Protein (mouse)
C1q Protein (mouse)
0 Images
Referencia número: HY-NP0194A
C1q Protein (mouse) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (mouse) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune
and non-immune cells. C1q Protein (mouse) can be used for the research of mutiple disease .
loading...
    loading...
View All Sizes
Dezamizumab
Dezamizumab
0 Images
Referencia número: HY-P99358
No. CAS: 1662664-56-3
Synonyms: GSK 2398852; Anti-Serum Amyloid P/SAP Reference Antibody (dezamizumab)

Target:  

Complement System

Áreas de investigación:  

Inflammation/Immunology

Dezamizumab (GSK 2398852) is a fully humanized clonal IgG1 antibody against serum amyloid P component (SAP) with complement activation and amyloid clearance-inducing activities. Dezamizumab binds to SAP associated with amyloid deposits to form complexes that activate complement and mediate phagocytic clearance, triggering activation of the classical complement pathway. Dezamizumab can be used for the research of systemic amyloidosis .
loading...
    loading...
View All Sizes
Riliprubart
Riliprubart
0 Images
Referencia número: HY-P990091
No. CAS: 2756228-76-7
Synonyms: SAR 445088

Target:  

Complement System Fc Receptor (FcR)

Áreas de investigación:  

Neurological Disease Inflammation/Immunology

Riliprubart (SAR 445088) is a selective anti-C1s humanized IgG4 monoclonal antibody with mutations that enhance its binding to the neonatal Fc receptor. Riliprubart blocks activation of the classical complement pathway, prevents the formation of the C3 convertase C4b2a, and inhibits complement-mediated hemolytic activity. Riliprubart can be used in research related to classical complement-mediated diseases, cold agglutinin disease, and chronic inflammatory demyelinating polyneuropathy. For the isotype control of Riliprubart, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
loading...
    loading...
View All Sizes
Cemdisiran
Cemdisiran
0 Images
Referencia número: HY-145720
No. CAS: 1639264-46-2
Synonyms: ALN-CC5
Target:  

Complement System Small Interfering RNA (siRNA)

Áreas de investigación:  

Metabolic Disease

Cemdisiran (ALN-CC5) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases .
loading...
    loading...
View All Sizes
Empasiprubart
Empasiprubart
0 Images
Referencia número: HY-P990025
No. CAS: 2579031-19-7
Synonyms: ARGX-117

Target:  

Complement System

Áreas de investigación:  

Inflammation/Immunology

Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models .
loading...
    loading...
View All Sizes
Ganodermanondiol
Ganodermanondiol
0 Images
Referencia número: HY-N2996
No. CAS: 107900-76-5
Category:  

Infection Triterpenes Microorganisms Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields

Target:  

HIV Protease

Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC50 of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC50 of 41.7μM .
loading...
    loading...
View All Sizes
C1q Protein (rat)
C1q Protein (rat)
0 Images
Referencia número: HY-NP0194C
C1q Protein (rat) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rat) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune
and non-immune cells. C1q Protein (rat) can be used for the research of mutiple disease .
loading...
    loading...
View All Sizes
PIC1 PA
PIC1 PA
0 Images
Referencia número: HY-P10827
No. CAS: 1356469-36-7
Target:  

Complement System

Áreas de investigación:  

Inflammation/Immunology

PIC1 PA, a 15 amino-acid peptide, is a potent PIC1 analog that inhibits classical pathway mediated complement activation. PIC1 PA functionally disrupts the C1s-C1r-C1r-C1s/MASPs interaction with collagen-like region (CLR) of C1q/MBL, respectively. PIC1 PA specifically binds to the CLR of C1q and bounds to purified C1q with a mean equilibrium dissociation constant (KD) of 33.3 nM .
loading...
    loading...
View All Sizes
ANX-M1 (Human IgG1)
ANX-M1 (Human IgG1)
0 Images
Referencia número: HY-P991886

Target:  

Complement System

Áreas de investigación:  

Neurological Disease

ANX-M1 is a blood-brain barrier-permeable anti-C1q antibody. ANX-M1 can slow down the progression of retinal degeneration following photo-oxidative damage. ANX-M1 has been incorporated into nanocarriers to evaluate its brain delivery efficacy in a mouse model of Alzheimer's disease. ANX-M1 is applicable for research on age-related macular degeneration and Alzheimer's disease [1] .
loading...
    loading...
View All Sizes
Versicolactone B
Versicolactone B
0 Images
Referencia número: HY-N12265
No. CAS: 108885-62-7
Category:  

Human Gut Microbiota Metabolites Viola philippica Cav. Microorganisms Terpenoids Sesquiterpenes Violaceae Plants Endogenous metabolite

Target:  

Others

Versicolactone B is a sesquiterpene that can be isolated from Viola yedoensis. Versicolactone B exhibits anti-complement activity against the classical pathway and the alternative pathway .
loading...
    loading...
View All Sizes
C1q Protein (rabbit)
C1q Protein (rabbit)
0 Images
Referencia número: HY-NP0194B
C1q Protein (rabbit) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rabbit) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune
and non-immune cells. C1q Protein (rabbit) can be used for the research of mutiple disease .
loading...
    loading...
View All Sizes
Pulchinenoside J
Pulchinenoside J
0 Images
Referencia número: HY-N19128
No. CAS: 1476801-10-1
Category:  

Triterpenes Terpenoids Ranunculaceae Plants Pulsatilla chinensis (Bunge) Regel

Target:  

Complement System

Pulchinenoside J is a lupane-type triterpenoid saponin and a complement system inhibitor that acts via the classical pathway. Pulchinenoside J can be isolated from the roots of Pulsatilla chinensis .
loading...
    loading...
View All Sizes
SHR-2010
SHR-2010
0 Images
Referencia número: HY-P992463

Target:  

Ser/Thr Protease

Áreas de investigación:  

Endocrinology

SHR-2010 is a fully humanized monoclonal antibody targeting MASP-2. SHR-2010 selectively inhibits lectin pathway activation without affecting classical or alternative complement pathways. SHR-2010 can be used for the research of IgA nephropathy .
loading...
    loading...
View All Sizes
Ruxoprubart
Ruxoprubart
0 Images
Referencia número: HY-P991022
No. CAS: 2842046-67-5
Synonyms: NM8074

Target:  

Complement System

Áreas de investigación:  

Endocrinology

Ruxoprubart (NM8074) is an inhibitor of complement factor B (Bb subunit). Ruxoprubart selectively binds to active Bb to inhibit the alternative complement pathway without affecting the classical complement pathway. By blocking the activities of AP C3 and C5 convertases, Ruxoprubart effectively inhibits red blood cell hemolysis and reduces C3b deposition, thereby preventing intravascular and extravascular hemolysis. Ruxoprubart can be used in research related to paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, C3 glomerulopathy, and IgA nephropathy .
loading...
    loading...
View All Sizes
Ebribafusp alfa
Ebribafusp alfa
0 Images
Referencia número: HY-P990955
No. CAS: 2839652-75-2
Synonyms: ADX-097

Target:  

CD3 Complement System

Áreas de investigación:  

Inflammation/Immunology

Ebribafusp alfa (ADX-097) comprising a humanized anti-C3d monoclonal antibody linked to two moieties of the first five consensus repeats of factor H (fH1-5). Ebribafusp alfa binds C3d and related fragments, catalyzes AP convertase dissociation, acts as a factor I co-factor for C3b cleavage, and delivers fH1-5 moieties to C3d-deposited tissues for local complement inhibition without systemic blockade. Ebribafusp alfa reduces glomerular C3 deposition, proteinuria, urine albumin-creatinine ratios, and urine soluble C5b-9 levels, preserves podocyte foot-process architecture, inhibits skin complement activation, and localizes to UVB-damaged primate skin. Ebribafusp alfa can be used for the research of membranous nephropathy, bullous pemphigoid, discoid lupus erythematosus, C3 glomerulopathy, IgA nephropathy, and lupus nephritis .
loading...
    loading...
View All Sizes
Assay Types