SHR-2010
SHR-2010 is a fully humanized monoclonal antibody targeting MASP-2. SHR-2010 selectively inhibits lectin pathway activation without affecting classical or alternative complement pathways. SHR-2010 can be used for the research of IgA nephropathy.
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
Human IgG4 kappa
Human
SHR-2010 (0.390625-50 nM; 60 s) binds with high affinity to human and rhesus monkey MASP-2 (KD of 3.49×10-10 M and 1.38×10-10 M, respectively) and weak affinity to mouse MASP-2 (KD = 3.81×10-8 M)[1].
SHR-2010 (30 min with serum at 4°C) potently inhibits the lectin pathway in human serum (IC50 = 6.44 nM) and rhesus monkey serum (IC50 = 144.2 nM) but has no effect on rodent serum lectin pathway activity[1].
SHR-2010 (3.2-2000 nM; 30 min) selectively inhibits only the lectin pathway, with no effect on the classical or alternative complement pathways in human serum at concentrations up to 2000 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | Cmax | AUC0-t | AUC0-∞ | Vd | CL | MRT | Bioavailability |
|---|---|---|---|---|---|---|---|---|---|---|
| Rhesus monkey[1] | 0.5 mg/kg | i.v. | 226.3 h | 10.6 μg/mL | 1230 μg·h/mL | 1463 μg·h/mL | 135.9 mL/kg | 0.51 mL/h/kg | 182.4 h | / |
| Rhesus monkey[1] | 1.5 mg/kg | i.v. | 140.4 h | 43.6 μg/mL | 5068.5 μg·h/mL | 5188.9 μg·h/mL | 64.1 mL/kg | 0.3 mL/h/kg | 191.9 h | / |
| Rhesus monkey[1] | 5 mg/kg | i.v. | 175.9 h | 148.4 μg/mL | 28075.3 μg·h/mL | 30433 μg·h/mL | 39.4 mL/kg | 0.18 mL/h/kg | 257.4 h | / |
| Rhesus monkey[1] | 5 mg/kg | s.c. | 142.8 h | 74.6 μg/mL | 29347.2 μg·h/mL | 31336.5 μg·h/mL | 31.3 mL/kg | 0.18 mL/h/kg | 275.8 h | 104.5 % |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rhesus monkeys[1]
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Dosage:0.5; 1.5; 5 mg/kg
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Administration:i.v. or s.c. (5 mg/kg); single dose
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Result:Achieved maximum lectin pathway inhibition at 1 hour post single 5 mg/kg i.v. administration, with inhibitory effects persisting for 408 hours.
Maintained serum concentrations above 30,000 ng/mL and lectin pathway inhibition above 65% for 408 hours post single 5 mg/kg i.v. administration.
Exhibited dose-dependent inhibition of the lectin pathway in rhesus monkey serum.
Produced 65.8-80.1% lectin pathway inhibition persisting for 408 hours after a single 5 mg/kg intravenous dose.
MASP2
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SHR-2010 Related Classifications
HY-P992463 Related Classifications
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