2839652-75-2
Chemical Structure
Ebribafusp alfa
Synonym(s): ADX-097
- CAS No.: 2839652-75-2
- Formula:N/A
- Molecular Weight:213.781 kDa
SMILES: [Ebribafusp alfa]
Biological Activity: Ebribafusp alfa (ADX-097) is a bifunctional fusion protein composed of a humanized anti-C3d monoclonal antibody linked to the first five common repeat (fH1-5) domains of two complement factors H. Ebribafusp alfa is a tissue-targeted complement inhibitor designed to inhibit complement activity at the lesion site while minimizing systemic complement blockade. Ebribafusp alfa can be used for research on kidney diseases, lupus nephritis, and complement component 3 glomerulonephropathy[1][2]. The recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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Ebribafusp alfa | 96.40% | Ebribafusp alfa (ADX-097) is a bifunctional fusion protein composed of a humanized anti-C3d monoclonal antibody linked to the first five common repeat (fH1-5) domains of two complement factors H. Ebribafusp alfa is a tissue-targeted complement inhibitor designed to inhibit complement activity at the lesion site while minimizing systemic complement blockade. Ebribafusp alfa can be used for research on kidney diseases, lupus nephritis, and complement component 3 glomerulonephropathy. The recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003). | ||||||||||||||||||||
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- [1]. POS-042 C3d-Directed Factor H Targeting Delivers Potent and Durable Complement Inhibition and Disease-Modifying Efficacy In Kidney and Skin Without Inhibiting Systemic Complement.
- [2]. ADX-097, a Tissue-Targeted Complement Inhibitor for the Treatment of Kidney Diseases: Phase 1 Results in Healthy Participants and Model-Informed Phase 2 Dose Selection
Keywords
