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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
paracetamol
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "paracetamol" in MCE Product Catalog:
74
74 Publications Verification
Synonyms: paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide
74
74 Publications Verification
Synonyms: paracetamol (Standard); 4-Acetamidophenol (Standard); 4'-Hydroxyacetanilide (Standard)
Áreas de investigación:
Acetaminophen (Standard) is the analytical standard of Acetaminophen. This product is intended for research and analytical applications. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
2
2 Cited Publications
Synonyms: APAP-Cys TFA
Target:
Áreas de investigación:
Paracetamol-cysteine (TFA) is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (HY-66005) .
1
1 Cited Publications
Synonyms: Salipran
Target:
Áreas de investigación:
Benorylate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid. Benorylate has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis .
Referencia número: HY-66005S
No. CAS: 64315-36-2
Synonyms: paracetamol-d4; 4-Acetamidophenol-d4; 4'-Hydroxyacetanilide-d4
Referencia número: HY-W015600
No. CAS: 614-80-2
Synonyms: Orthocetamol
Áreas de investigación:
2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe 2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .
Target:
Áreas de investigación:
Propacetamol hydrochloride is an orally active prodrug of paracetamol and an inducer of acute liver injury models, with multiple properties including antinociception, antioxidation and gastroprotection. Propacetamol hydrochloride potentiates Tramadol and attenuates Aspirin (HY-14654)-induced gastric mucosal damage and lipid peroxidation. Under specific conditions, Propacetamol hydrochloride also acts as a hepatotoxic inducer, triggering acute liver injury, oxidative stress and apoptosis, with strain differences in toxicity sensitivity. Propacetamol hydrochloride can be used in the research of acute liver injury, drug-induced hepatotoxicity and gastric mucosal damage .
Referencia número: HY-66005S1
No. CAS: 60902-28-5
Synonyms: paracetamol-d3; 4-Acetamidophenol-d3; 4'-Hydroxyacetanilide-d3
Target:
Áreas de investigación:
Propacetamol is an orally active prodrug of Acetaminophen (HY-66005), which exerts antipyretic and analgesic effects after metabolism. Propacetamol reduces Aspirin (ASA) (HY-14654)-induced elevation of malondialdehyde (MDA) in gastric mucosa and plasma, regulates the levels of gastric mucosal glutathione (GSH and GSSG) to maintain cellular antioxidant defense, and increases gastric mucosal uric acid (UA) levels. Propacetamol exerts a dose-dependent protective effect against ASA-induced gastric mucosal damage in rats. Propacetamol can be used for the study of gastric mucosal injury by interfering with oxidative stress .
Referencia número: HY-66005S2
No. CAS: 1219798-53-4
Synonyms: paracetamol-d7; 4-Acetamidophenol-d7; 4'-Hydroxyacetanilide-d7
Referencia número: HY-W015600R
No. CAS: 614-80-2
Synonyms: Orthocetamol (Standard)
Áreas de investigación:
2-Acetamidophenol (Standard) is the analytical standard of 2-Acetamidophenol. This product is intended for research and analytical applications. 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe 2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .
Referencia número: HY-139093
No. CAS: 53446-10-9
Synonyms: APAP-Cys
Target:
Áreas de investigación:
Referencia número: HY-66005S4
No. CAS: 360769-21-7
Synonyms: paracetamol-13C2,15N; 4-Acetamidophenol-13C2,15N; 4'-Hydroxyacetanilide-13C2,15N
Referencia número: HY-107795R
No. CAS: 5003-48-5
Synonyms: Salipran (Standard)
Áreas de investigación:
Benorilate (Standard) is the analytical standard of Benorilate. This product is intended for research and analytical applications. Benorylate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid. Benorylate has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis .
Referencia número: HY-W015600S
No. CAS: 122258-87-1
Synonyms: Orthocetamol-d3
Referencia número: HY-W016034
No. CAS: 120595-80-4
Synonyms: p-Acetamidophenyl β-D-glucuronide sodium salt; p-AAPG sodium salt
Target:
Áreas de investigación:
Acetaminophen glucuronide is a safe and effective
antipyretic analgesic. Acetaminophen glucuronide is potentially toxic to liver
and kidney .
Referencia número: HY-W042159
No. CAS: 3964-54-3
Target:
Áreas de investigación:
Paracetamol impurity 1 is an impurity of Paracetamol.
Referencia número: HY-66005S3
No. CAS: 2132405-57-1
Synonyms: paracetamol-13C6; 4-Acetamidophenol-13C6; 4'-Hydroxyacetanilide-13C6
Target:
Áreas de investigación:
4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic agent .
Referencia número: HY-W739619
No. CAS: 2470331-44-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
