TDI-011536
Based on 4 publication(s) in Google Scholar
TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.
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- Pureza: 99.87%
- No. CAS: 2687970-96-1
- Fòrmula: C19H16N4O2S
- Peso molecular:364.42
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) TDI-011536
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Ver todos los productos específicos de isoformas YAP
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Actividad biológica
Lats kinase[1].
TDI-011536 (3 μM; 24 h) reduces Yap phosphorylation and (3 μM; 5 days) induces proliferation of Müller glia in human retinal organoids[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human retinal organoids
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Concentration:3 µM
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Incubation Time:24 h, 5 days
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Result:Supressed Yap phosphorylation and promoted Müller glia proliferation.
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection)[1].
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Dosage:200 mg/kg
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Administration:Intraperitoneal injections; once.
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Result:Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.
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Animal Model:Male 8-week-old mice (cryolesion model)[1].
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Dosage:100 mg/kg
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Administration:Intraperitoneal injections; once daily for 2 or 3 days.
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Result:Promoted cardiomyocytes proliferation.
Chemical Information
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No. CAS 2687970-96-1
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Appearance Solid
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Peso molecular 364.42
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Fòrmula C19H16N4O2S
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Color White to off-white
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SMILES
O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3CO)/N3CC4=CC=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Free Radic Biol Med
Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling. [Abstract]2025 Nov 22:243:452-465. PMID: 41285255 -
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TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.
Mitochondrial morphology visualized by MitoTracker staining following TMAO treatment, with or without the Hippo pathway inhibitor TDI-011536 (4 μM, 24 h). Scale bar, 20 μm.
TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.
Western blot of mitochondrial dynamics proteins (Fis1, p-Drp1/Drp1, Drp1, Mfn1, Mfn2) following TMAO and TDI-011536 (4 μM, 24 h) treatment.
TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.
TM3 cells were treated with TMAO, with or without TDI-011536 (4 μM, 24 h) treatment, and ATP levels were measured.
TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.
Mitochondrial membrane potential via JC-10 assay. Scale bar, 10 μm. Relative ROS generation in TM3 cells following treatment with TMAO, with or without TDI-011536 (4 μM, 24 h).
TDI-011536 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 18.
Cyp11a1 and StAR expression in TM3 cells following TMAO treatment, with or without TDI-011536 (4 μM, 24 h).
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Solvente y solubilidad
DMSO : 125 mg/mL (343.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7441 mL | 13.7204 mL | 27.4409 mL | 68.6022 mL |
| 5 mM | 0.5488 mL | 2.7441 mL | 5.4882 mL | 13.7204 mL | |
| 10 mM | 0.2744 mL | 1.3720 mL | 2.7441 mL | 6.8602 mL | |
| 15 mM | 0.1829 mL | 0.9147 mL | 1.8294 mL | 4.5735 mL | |
| 20 mM | 0.1372 mL | 0.6860 mL | 1.3720 mL | 3.4301 mL | |
| 25 mM | 0.1098 mL | 0.5488 mL | 1.0976 mL | 2.7441 mL | |
| 30 mM | 0.0915 mL | 0.4573 mL | 0.9147 mL | 2.2867 mL | |
| 40 mM | 0.0686 mL | 0.3430 mL | 0.6860 mL | 1.7151 mL | |
| 50 mM | 0.0549 mL | 0.2744 mL | 0.5488 mL | 1.3720 mL | |
| 60 mM | 0.0457 mL | 0.2287 mL | 0.4573 mL | 1.1434 mL | |
| 80 mM | 0.0343 mL | 0.1715 mL | 0.3430 mL | 0.8575 mL | |
| 100 mM | 0.0274 mL | 0.1372 mL | 0.2744 mL | 0.6860 mL |
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