2. Gene
  3. MIR1246 - microRNA 1246 Gene

MIR1246 - microRNA 1246 Gene

  • Gene
  • Agent
Homo sapiens

Also known as MIRN1246; hsa-mir-1246

Gene ID: 100302142 | Gene type: ncRNA

About MIR1246

This gene has 1 transcript (splice variant).

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
28159925 GOA
enables mRNA base-pairing translational repressor activity IDA
IDA: Inferred from direct assay
28159925 GOA
Biological Process GO Annotation Evidence Reference Source
involved in miRNA-mediated post-transcriptional gene silencing IDA
IDA: Inferred from direct assay
28159925 GOA
acts upstream of positive regulation of NF-kappaB transcription factor activity IGI
IGI: Inferred from genetic interaction
28159925 GOA
acts upstream of positive regulation of gene expression IDA
IDA: Inferred from direct assay
28159925 GOA
acts upstream of positive regulation of tumor necrosis factor-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
28159925 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00144 hsa-miR-1246 mimic 90.42% Unkown
HY-RI00144 hsa-miR-1246 inhibitor 99.03% Unkown
HY-R00144A hsa-miR-1246 agomir 91.98% Unkown
HY-RI00144A hsa-miR-1246 antagomir 96.14% Unkown