TSFM - Ts translation elongation factor, mitochondrial Gene

Also Known as EFTS; EFTSMT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10102

About TSFM

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:57,782,787-57,802,856 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 18.8), kidney (RPKM 13.0) and 25 other tissues.

Summary

This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined Oxidative Phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

TSFM Products (4)

mRNA	Protein	Name
NM_001172695.2	NP_001166166.1	elongation factor Ts, mitochondrial isoform 3 precursor
NM_001172696.2	NP_001166167.1	elongation factor Ts, mitochondrial isoform 1 precursor
NM_001172697.2	NP_001166168.1	elongation factor Ts, mitochondrial isoform 4 precursor
NM_005726.6	NP_005717.3	elongation factor Ts, mitochondrial isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of mitochondrial translation	IDA IDA: Inferred from direct assay	27677415	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSFM Protein Structure

UBA

EF_TS

0
100
200
300
325 a.a.

Protein Preferred Names	Protein Names
elongation factor Ts, mitochondrial	mitochondrial elongation factor Ts

TSFM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TSFM	P43897	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	TSFM	P43897	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	TSFM	P43897	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	TSFM	P43897	CCDC89	Homo sapiens	Q8N998	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	CCDC89	Homo sapiens	Q8N998	Validated Y2H	32296183
Intra	TSFM	P43897	CCDC89	Homo sapiens	Q8N998	Y2H Array	32296183
Intra	TSFM	P43897	CPLX2	Homo sapiens	Q6PUV4	Validated Y2H	32296183
Intra	TSFM	P43897	CPLX2	Homo sapiens	Q6PUV4	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	CPLX2	Homo sapiens	Q6PUV4	Y2H Array	32296183
Intra	TSFM	P43897	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	TSFM	P43897	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	TSFM	P43897	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	TSFM	P43897	CEP70	Homo sapiens	Q8NHQ1	Y2H Bait-Prey Pool	25910212
Intra	TSFM	P43897	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	TSFM	P43897	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	TSFM	P43897	RALBP1	Homo sapiens	Q15311	Y2H Prey Pooling	32296183
Intra	TSFM	P43897	RALBP1	Homo sapiens	Q15311	Y2H Array	32296183
Intra	TSFM	P43897	RALBP1	Homo sapiens	Q15311	Y2H Bait-Prey Pool	25910212
Intra	TSFM	P43897	RALBP1	Homo sapiens	Q15311	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

TSFM Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82779	Elongation Factor Ts Antibody (YA2524)	WB	Human
HY-P82779A	Elongation Factor Ts Antibody (YA2524)(PBS only)	WB	Human
HY-P86286	Elongation Factor Ts Antibody (YA5978)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Combined Oxidative Phosphorylation Deficiency 3	Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3 COXPD3 Encephalomyopathy, Respiratory Failure, And Lactic Acidosis Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis Fatal Mitochondrial Disease Due To Coxpd3 Concentric Cardiomyopathy Hypotonia And Lactic Acidosis Encephalomyopathy Respiratory Failure And Lactic Acidosis Encephalomyopathy With Respiratory Failure And Lactic Acidosis Combined Oxidative Phosphorylation Deficiency, Type 3
Nephrotic Syndrome, Type 21	NPHS21 Nephrotic Syndrome Type 21 Nephrotic Syndrome 21
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Combined Oxidative Phosphorylation Deficiency
Combined Oxidative Phosphorylation Deficiency 39	COXPD39 Combined Oxidative Phosphorylation Defect Type 39 Gfm2-Related Combined Oxidative Phosphorylation Defect
Combined Oxidative Phosphorylation Deficiency 1	Hepatoencephalopathy Due To Combined Oxidative Phosphorylation Defect Type 1 COXPD1 Early Fatal Progressive Hepatoencephalopathy Hepatoencephalopathy Due To Coxpd1 Combined Oxidative Phosphorylation Deficiency, Type 1 Hepatoencephalopathy, Early Fatal Progressive Hepatoencephalopathy Early Fatal Progressive
Combined Oxidative Phosphorylation Deficiency 4	COXPD4 Combined Oxidative Phosphorylation Defect Type 4 Combined Oxidative Phosphorylation Deficiency, Type 4
Nephrotic Syndrome, Type 2	NPHS2 Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive Srn1 Nephrotic Syndrome Type 2 Steroid-Resistant Autosomal Recessive Nephrotic Syndrome Nephrotic Syndrome 2 Autosomal Recessive Steroid-Resistant Nephrotic Syndrome Srn Nephrotic Syndrome, Type 2, Susceptibility To Idiopathic Nephrotic Syndrome
Metabolic Acidosis
Myopathy, Lactic Acidosis, And Sideroblastic Anemia
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Endemic Typhus	Murine Typhus Cat Flea Rickettsiosis Fleaborne Typhus Rat-Flea Typhus Rickettsia Felis Spotted Fever Shop Typhus Toulon Typhus Urban Typhus Urban Typhus Of Malaya Flea-Borne Typhus Endemic Flea-Borne Typhus
Myoclonic Epilepsy Associated With Ragged-Red Fibers	Merrf Syndrome MERRF Fukuhara Syndrome Myoclonic Epilepsy Associated With Ragged Red Fibers Myoencephalopathy Ragged-Red Fiber Disease Myoclonic Epilepsy - Ragged Red Fibers Myoclonus Epilepsy And Ragged Red Fibers Myoclonus With Epilepsy And With Ragged Red Fibers Myoclonic Epilepsy With Ragged Red Fibers Myoclonic Epilepsy With Ragged-Red Fibers Fukuhara Disease Myoclonus Epilepsy Associated With Ragged-Red Fibres Myoclonus With Epilepsy With Ragged Red Fibers
Leigh Syndrome	Leigh Disease Infantile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency LS Sne Leigh'S Disease Leigh Syndrome Due To Mitochondrial Complex I Deficiency Necrotizing Encephalopathy, Infantile Subacute, Of Leigh Subacute Necrotizing Encephalomyelopathy Necrotizing Encephalopathy Infantile Subacute Of Leigh Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency Infantile Necrotizing Encephalomyelopathy Juvenile Subacute Necrotizing Encephalomyelopathy Leigh'S Necrotizing Encephalopathy Subacute Necrotizing Encephalopathy Juvenile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency Leigh Syndrome Due To Mitochondrial Complex V Deficiency Encephalopathy, Subacute Necrotizing, Infantile Encephalopathy, Subacute Necrotizing, Juvenile Maternally Inherited Leigh Syndrome Subacute Necrotising Encephalomyelopathy Subacute Necrotising Encephalopathy
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes	Melas Syndrome MELAS Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15141	TSFM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19967	Tsfm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26470	Tsfm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TSFM	MGD	MGI:1913649
Rattus norvegicus	TSFM	RGD	RGD:1593058
Macaca mulatta	TSFM	VGNC	VGNC:78660
Bos taurus	TSFM	VGNC	VGNC:36413
Felis catus	TSFM	VGNC	VGNC:66612
Others	TSFM	NCBI