TSPAN1 - tetraspanin 1 Gene

Also Known as NET1; TM4C; TM4SF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10103

About TSPAN1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:46,175,087-46,196,489 (from NCBI)

This gene has 9 transcripts (splice variants), 194 orthologues and 32 paralogues. Biased expression in colon (RPKM 237.8), prostate (RPKM 118.0) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

TSPAN1 Products (1)

mRNA	Protein	Name
NM_005727.4	NP_005718.2	tetraspanin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21836059	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein stabilization	IDA IDA: Inferred from direct assay	21836059	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12115476	GOA
located in membrane	IDA IDA: Inferred from direct assay	12115476	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22378020	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21836059	GOA
located in vesicle	IDA IDA: Inferred from direct assay	21836059	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN1 Protein Structure

Tetraspannin

0
100
200
241 a.a.

Protein Preferred Names	Protein Names
tetraspanin-1	tetraspan 1

TSPAN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TSPAN1	O60635	TFAM	Homo sapiens	Q00059	Validated Y2H	32296183
Intra	TSPAN1	O60635	TFAM	Homo sapiens	Q00059	Y2H Array	32296183
Intra	TSPAN1	O60635	TFAM	Homo sapiens	Q00059	Y2H Prey Pooling	32296183
Intra	TSPAN1	O60635	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	TSPAN1	O60635	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	TSPAN1	O60635	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	TSPAN1	O60635	SLC19A2	Homo sapiens	O60779	Pull Down	21836059
Intra	TSPAN1	O60635	SLC19A2	Homo sapiens	O60779	Y2H	21836059
Intra	TSPAN1	O60635	SLC19A2	Homo sapiens	O60779	Anti Tag CoIP	21836059
Intra	TSPAN1	O60635	SLC19A2	Homo sapiens	O60779	Confocal	21836059

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TSPAN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77260	TSPAN1 Protein, Human (HEK293, His)	O60635 (Y110-N211)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77261	TSPAN1 Protein, Human (HEK293, rFc)	O60635 (Y110-N211)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77262	TSPAN1 Protein, Human (HEK293, Fc)	O60635 (Y110-N211)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 76	RP76 Retinitis Pigmentosa, Type 76
Muscle Eye Brain Disease	Muscle-Eye-Brain Disease Muscle-Eye-Brain Syndrome Meb Muscular Dystrophy-Dystroglycanopathy Congenital With Brain And Eye Anomalies A3 Meb Syndrome Santavuori Congenital Muscular Dystrophy
Muscular Dystrophy-Dystroglycanopathy , Type B, 3	MDDGB3 Muscular Dystrophy-Dystroglycanopathy , Type B3 Muscular Dystrophy, Congenital, Pomgnt1-Related Muscular Dystrophy-Dystroglycanopathy Type B3 Congenital Muscular Dystrophy Pomgnt1-Related Muscular Dystrophy-Dystroglycanopathy Congenital With Impaired Intellectual Development B3 Muscular Dystrophy Congenital Pomgnt1-Related Dystrophy, Muscular, Dystroglycanopathy , Type B3
Muscular Dystrophy-Dystroglycanopathy , Type C, 3	Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2o MDDGC3 Lgmd2o Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 15 Lgmdr15 Muscular Dystrophy-Dystroglycanopathy Limb-Girdle Pomgnt1-Related Muscular Dystrophy, Limb-Girdle, Type 2o Muscular Dystrophy-Dystroglycanopathy, Limb-Girdle, Pomgnt1-Related Muscular Dystrophy-Dystroglycanopathy Type C3 Pomgnt1-Related Limb-Girdle Muscular Dystrophy R15 Lgmd Type 2o Limb-Girdle Muscular Dystrophy Type 2o Pomgnt1-Related Lgmd R15 Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C3 Dystrophy, Muscular, Limb-Girdle, Type 2o
Congenital Muscular Dystrophy-Dystroglycanopathy Type A3	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A3 Mddga3 Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Pomgnt1-Related Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A3
Muscular Dystrophy-Dystroglycanopathy , Type A, 3	MDDGA3 Muscular Dystrophy-Dystroglycanopathy , Type A3 Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Pomgnt1-Related Muscular Dystrophy-Dystroglycanopathy Congenital With Brain And Eye Anomalies A3 Muscle-Eye-Brain Disease Pomgnt1-Related Walker-Warburg Syndrome Pomgnt1-Related Dystrophy, Muscular, Dystroglycanopathy , Type A3
Congenital Muscular Dystrophy-Dystroglycanopathy Type A	Congenital Muscular Alpha-Dystroglycanopathy With Brain And Eye Anomalies Mddga Klissencephaly Type 2 With Muscular And Ocular Involvement Lissencephaly Type 2 With Muscular And Ocular Involvement
Muscular Dystrophy-Dystroglycanopathy	Cmd Due To Dystroglycanopathy Congenital Muscular Dystrophy Due To Dystroglycanopathy Mddg Dystrophy, Muscular, Dystroglycanopathy
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Abnormality Of Glucagon Secretion	Glucagon Secretion Abnormality Abnormality Of Secretion Of Glucagon
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Usher Syndrome, Type Iiia	Usher Syndrome Type 3 Ush3 Usher Syndrome Type 3a USH3A Usher Syndrome, Type Iii Usher Syndrome, Type 3 Usher Syndrome, Type 3a Usher Syndrome Type Iiia Usher Syndrome 3a Usher'S Syndrome Type 3 Usher Syndrome Iii Usher Syndrome Type Iii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15157	TSPAN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20200	Tspan1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26704	Tspan1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSPAN1	RGD	RGD:1303308
Canis familiaris	TSPAN1	VGNC	VGNC:47910
Felis catus	TSPAN1	VGNC	VGNC:66624
Mus musculus	TSPAN1	MGD	MGI:1914055
Bos taurus	TSPAN1	VGNC	VGNC:36425
Macaca mulatta	TSPAN1	VGNC	VGNC:79263
Others	TSPAN1	NCBI