2. Gene
  3. MPZL2 - myelin protein zero like 2 Gene

MPZL2 - myelin protein zero like 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EVA; EVA1; DFNB111

Gene ID: 10205 | Gene type: protein coding

About MPZL2

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,253,416-118,264,297 (from NCBI)

This gene has 7 transcripts (splice variants), 255 orthologues, 6 paralogues and is associated with 2 phenotypes. Broad expression in esophagus (RPKM 92.3), urinary bladder (RPKM 53.8) and 14 other tissues.

Summary

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the Cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for Casein Kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

MPZL2 Products(2)

mRNA Protein Name
NM_005797.4 NP_005788.1 myelin protein zero-like protein 2 precursor
NM_144765.3 NP_658911.1 myelin protein zero-like protein 2 precursor

MPZL2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (30 - 141)

  • 0
  • 100
  • 200
  • 215 a.a.
Protein Preferred Names Protein Names

myelin protein zero-like protein 2

epithelial V-like antigen 1

Recombinant MPZL2 Proteins

Cat. No. Product Name Accession Purity
HY-P700717 MPZL2 Protein, Human (HEK293, hFc) O60487 (V27-L154) ≥95%

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 111

DFNB111

Autosomal Recessive Nonsyndromic Deafness 111

Autosomal Recessive Deafness 111

Deafness, Autosomal Recessive, 111
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
Exudative Vitreoretinopathy 4

EVR4

Vitreoretinopathy, Exudative 4

Vitreoretinopathy, Exudative, Type 4
Deafness And Myopia

High Myopia-Sensorineural Deafness Syndrome

DFNMYP

Deafness And Myopia Syndrome

Deafness, Cochlear, Plus

High Myopia And Sensorineural Deafness

Myopia And Deafness

High Myopia-Sensorineural Hearing Loss Syndrome
Exudative Vitreoretinopathy 2, X-Linked

EVR2

Evrx

Fevrx

X-Linked Exudative Vitreoretinopathy 2

Exudative Vitreoretinopathy, Familial, 2

Fevr, X-Linked

Vitreoretinopathy, Exudative 2

Exudative Vitreoretinopathy Familial 2

Fevr X-Linked

X-Linked Familial Exudative Vitreoretinopathy

Vitreoretinopathy, Exudative, X-Linked, Type 2

Exudative Vitreoretinopathy, Familial, X-Linked Recessive
Exudative Vitreoretinopathy 3

EVR3
Deafness, Autosomal Dominant 65

DFNA65

Autosomal Dominant Nonsyndromic Deafness 65

Autosomal Dominant Deafness 65

Deafness, Autosomal Dominant, 65

Deafness, Autosomal Dominant, Type 65
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08635 MPZL2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MPZL2 VGNC VGNC:31593
Felis catus MPZL2 VGNC VGNC:63577
Rattus norvegicus MPZL2 RGD RGD:1307196
Mus musculus MPZL2 MGD MGI:1289160
Macaca mulatta MPZL2 VGNC VGNC:107459
Canis familiaris MPZL2 VGNC VGNC:43355
Others MPZL2 NCBI