MPZL2 - myelin protein zero like 2 Gene

Also Known as EVA; EVA1; DFNB111

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10205

About MPZL2

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,253,416-118,264,297 (from NCBI)

This gene has 7 transcripts (splice variants), 255 orthologues, 6 paralogues and is associated with 2 phenotypes. Broad expression in esophagus (RPKM 92.3), urinary bladder (RPKM 53.8) and 14 other tissues.

Summary

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the Cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for Casein Kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

MPZL2 Products (2)

mRNA	Protein	Name
NM_005797.4	NP_005788.1	myelin protein zero-like protein 2 precursor
NM_144765.3	NP_658911.1	myelin protein zero-like protein 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPZL2 Protein Structure

V-set

0
100
200
215 a.a.

Protein Preferred Names	Protein Names
myelin protein zero-like protein 2	epithelial V-like antigen 1

MPZL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MPZL2	O60487	MPZL3	Homo sapiens	Q6UWV2	Protein Array	21982860
Intra	MPZL2	O60487	MPZL3	Homo sapiens	Q6UWV2	SPR	21982860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MPZL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700717	MPZL2 Protein, Human (HEK293, hFc)	O60487 (V27-L154)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 111	DFNB111 Autosomal Recessive Nonsyndromic Deafness 111 Autosomal Recessive Deafness 111 Deafness, Autosomal Recessive, 111
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
Exudative Vitreoretinopathy 4	EVR4 Vitreoretinopathy, Exudative 4 Vitreoretinopathy, Exudative, Type 4
Deafness And Myopia	High Myopia-Sensorineural Deafness Syndrome DFNMYP Deafness And Myopia Syndrome Deafness, Cochlear, Plus High Myopia And Sensorineural Deafness Myopia And Deafness High Myopia-Sensorineural Hearing Loss Syndrome
Exudative Vitreoretinopathy 2, X-Linked	EVR2 Evrx Fevrx X-Linked Exudative Vitreoretinopathy 2 Exudative Vitreoretinopathy, Familial, 2 Fevr, X-Linked Vitreoretinopathy, Exudative 2 Exudative Vitreoretinopathy Familial 2 Fevr X-Linked X-Linked Familial Exudative Vitreoretinopathy Vitreoretinopathy, Exudative, X-Linked, Type 2 Exudative Vitreoretinopathy, Familial, X-Linked Recessive
Exudative Vitreoretinopathy 3	EVR3
Deafness, Autosomal Dominant 65	DFNA65 Autosomal Dominant Nonsyndromic Deafness 65 Autosomal Dominant Deafness 65 Deafness, Autosomal Dominant, 65 Deafness, Autosomal Dominant, Type 65

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08635	MPZL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MPZL2	VGNC	VGNC:31593
Felis catus	MPZL2	VGNC	VGNC:63577
Rattus norvegicus	MPZL2	RGD	RGD:1307196
Mus musculus	MPZL2	MGD	MGI:1289160
Macaca mulatta	MPZL2	VGNC	VGNC:107459
Canis familiaris	MPZL2	VGNC	VGNC:43355
Others	MPZL2	NCBI