DENND4A - DENN domain containing 4A Gene

Homo sapiens

Also known as IRLB; MYCPBP

Gene ID: 10260 | Gene type: protein coding

About DENND4A

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:65,659,123-65,792,293 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 7.2), lymph node (RPKM 6.2) and 25 other tissues.

Summary

This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]

DENND4A Products(5)

mRNA	Protein	Name
NM_001144823.2	NP_001138295.1	C-myc promoter-binding protein isoform 1
NM_001320835.1	NP_001307764.1	C-myc promoter-binding protein isoform 3
NM_001376919.1	NP_001363848.1	C-myc promoter-binding protein isoform 2
NM_001376920.1	NP_001363849.1	C-myc promoter-binding protein isoform 2
NM_005848.4	NP_005839.3	C-myc promoter-binding protein isoform 2

DENND4A Protein Structure

uDENN

DENN

dDENN

0
300
600
900
1200
1500
1863 a.a.

Protein Preferred Names

Protein Names

C-myc promoter-binding protein

DENN domain-containing protein 4A

Related Diseases

Diseases

Alias

Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome	Syndromic Diarrhea
Tricho-Hepato-Enteric Syndrome	Sd/The
Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome	THES1
Phenotypic Diarrhea	Thes
Phenotypic Diarrhea Of Infancy	Diarrhea, Syndromic
Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa	Intractable Diarrhea With Phenotypic Anomalies
Syndromatic Diarrhea	Fatal Infantile Diarrhea With Trichorrhexis Nodosa

Alkuraya-Kucinskas Syndrome

ALKKUCS	Kiaa1109-Related Early Lethal Congenital Brain Malformations-Arthrogryposis Syndrome
Arthrogryposis

Spastic Paraplegia 39, Autosomal Recessive

SPG39	Ntemnd
Hereditary Spastic Paraplegia 39	Nte-Related Motor Neuron Disorder
Autosomal Recessive Spastic Paraplegia Type 39	Spastic Paraplegia Due To Neuropathy Target Esterase Mutation
Spastic Paraplegia Due To Nte Mutation	Spastic Paraplegia 39
Autosomal Recessive Spastic Paraplegia 39	Nte Related Motor Neuron Disorder
Paraplegia, Spastic, Type 39

Folic Acid Deficiency Anemia

Folate Deficiency Anaemia	Folic Acid Deficiency Anaemia
Folate Deficiency Anemia	Folate-Deficiency Anaemia
Folate-Deficiency Anemia	Folate-Deficient Megaloblastic Anaemia
Megaloblastic Anemia Due To Folate Deficiency	Anaemia Of Folate Deficiency
Folate Or Folic Acid Deficiency Anaemia Nos	Folic Acid Deficiency Anaemia Nos
Acquired Megaloblastic Anaemia Due To Nutritional Folate Deficiency	Dietary Folic Acid Deficiency Anaemia
Dietary Folate Deficiency Anaemia	Folate Deficiency Anaemia Due To Dietary Causes
Goat'S Milk Anaemia	Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Increased Requirement
Megaloblastic Anaemia Due To Increased Requirements Of Folate	Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Intestinal Disorders
Acquired Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate	Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03688	DENND4A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DENND4A	VGNC	VGNC:39890
Felis catus	DENND4A	VGNC	VGNC:61437
Mus musculus	DENND4A	MGD	MGI:2142979
Bos taurus	DENND4A	VGNC	VGNC:27999
Macaca mulatta	DENND4A	VGNC	VGNC:71697
Rattus norvegicus	DENND4A	RGD	RGD:1562639

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