CCNO - cyclin O Gene

Also Known as CCNU; UDG2; CILD29

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10309

About CCNO

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,231,152-55,233,608 (from NCBI)

This gene has 2 transcripts (splice variants), 231 orthologues, 18 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 3.3), stomach (RPKM 2.3) and 16 other tissues.

Summary

This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

CCNO Products (1)

mRNA	Protein	Name
NM_021147.5	NP_066970.3	cyclin-O

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	24747639	GOA
involved in mitotic cell cycle	IDA IDA: Inferred from direct assay	8419333	GOA
involved in multi-ciliated epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	24747639	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24747639	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	28860486	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNO Protein Structure

Cyclin_N

Cyclin_C

0
100
200
300
350 a.a.

Protein Preferred Names	Protein Names
cyclin-O	cyclin U

CCNO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCNO	P22674	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ciliary Dyskinesia, Primary, 29	Primary Ciliary Dyskinesia 29 CILD29 Ciliary Dyskinesia, Primary, 29, Without Situs Inversus Primary Ciliary Dyskinesia 29 Without Situs Inversus Primary Ciliary Dyskinesia Without Situs Inversus Dyskinesia, Ciliary, Primary, Type 29
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Bronchiectasis	Polynesian Bronchiectasis Kartagener Syndrome Bronchiectasis Nos
Chromosome 17q12 Duplication Syndrome	17q12 Microduplication Syndrome Trisomy 17q12 17q12 Duplication 17q12 Microduplication Dup(17)(Q12) Recurrent Duplication Of 17q12 17q12 Duplication Syndrome 17q12 Recurrent Duplication
Chronic Rhinitis	Rhinitis - Chronic Chronic Rhinitis Nos Rhinitis Rhinitis Nos
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Otorrhea	Discharging Ear
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations	Star Syndrome Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome Syndactyly With Renal And Anogenital Malformations STAR Syndactyly, Telecanthus, Anogenital And Renal Malformations Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Kartagener Syndrome	Kartagener'S Syndrome
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02138	CCNO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21306	Ccno Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27825	Ccno Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CCNO	VGNC	VGNC:52117
Bos taurus	CCNO	VGNC	VGNC:26977
Rattus norvegicus	CCNO	RGD	RGD:1565217
Macaca mulatta	CCNO	VGNC	VGNC:70824
Mus musculus	CCNO	MGD	MGI:2145534
Felis catus	CCNO	VGNC	VGNC:60567
Others	CCNO	NCBI