Epop - elongin BC and polycomb repressive complex 2 associated protein Gene

Mus musculus

Also known as E13; esPRC2p48; E130012A19Rik

Gene ID: 103551 | Gene type: protein coding

About Epop

Summary

Enables chromatin binding activity. Involved in histone H2B conserved C-terminal lysine deubiquitination; regulation of transcription by RNA polymerase II; and stem cell differentiation. Acts upstream of or within neuron fate commitment. Part of ESC/E(Z) complex and elongin complex. Orthologous to human EPOP (elongin BC and polycomb repressive complex 2 associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Epop Products(1)

mRNA	Protein	Name
NM_175332.3	NP_780541.2	elongin BC and Polycomb repressive complex 2-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	27863225	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23180766	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	27863226	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within neuron fate commitment	IDA IDA: Inferred from direct assay	23180766	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	23180766	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	27863226	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	27863225	MGI
involved in stem cell differentiation	IMP IMP: Inferred from mutant phenotype	27863225	MGI
involved in transcription elongation-coupled chromatin remodeling	IMP IMP: Inferred from mutant phenotype	27863226	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	27863225	MGI
part of elongin complex	IDA IDA: Inferred from direct assay	27863225	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

elongin BC and Polycomb repressive complex 2-associated protein

ES cell-specific PRC2 subunit p48	elongin and polycomb associated protein
embryonic stem cell-specific PRC2 subunit p48	uncharacterized protein C17orf96 homolog

Epop Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Epop	Q7TNS8	Suz12	Mus musculus	Q80U70	Anti Tag CoIP	23180766
Intra	Epop	Q7TNS8	Gtf2e2	Mus musculus	Q9D902	Anti Tag CoIP	23180766
Intra	Epop	Q7TNS8	Eed	Mus musculus	Q921E6	Anti Tag CoIP	23180766

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04447	EPOP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epop	NCBI	NCBI:100170841

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