Epop - elongin BC and polycomb repressive complex 2 associated protein Gene

Also Known as E13; esPRC2p48; E130012A19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 103551

Summary

Enables chromatin binding activity. Involved in histone H2B conserved C-terminal lysine deubiquitination; regulation of transcription by RNA polymerase II; and stem cell differentiation. Acts upstream of or within neuron fate commitment. Part of ESC/E(Z) complex and elongin complex. Orthologous to human EPOP (elongin BC and polycomb repressive complex 2 associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Epop Products (1)

mRNA Protein Name
NM_175332.3 NP_780541.2 elongin BC and Polycomb repressive complex 2-associated protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
27863225 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23180766 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
27863226 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within neuron fate commitment IDA
IDA: Inferred from direct assay
23180766 MGI
acts upstream of or within neuron fate commitment IMP
IMP: Inferred from mutant phenotype
23180766 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
27863226 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
27863225 MGI
involved in stem cell differentiation IMP
IMP: Inferred from mutant phenotype
27863225 MGI
involved in transcription elongation-coupled chromatin remodeling IMP
IMP: Inferred from mutant phenotype
27863226 MGI
Cellular Component GO Annotation Evidence References Source
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
27863225 MGI
part of elongin complex IDA
IDA: Inferred from direct assay
27863225 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

elongin BC and Polycomb repressive complex 2-associated protein

  • ES cell-specific PRC2 subunit p48

  • elongin and polycomb associated protein

  • embryonic stem cell-specific PRC2 subunit p48

  • uncharacterized protein C17orf96 homolog

Epop Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Epop Q7TNS8 Suz12 Mus musculus Q80U70
Anti Tag CoIP
23180766
Intra
Epop Q7TNS8 Gtf2e2 Mus musculus Q9D902
Anti Tag CoIP
23180766
Intra
Epop Q7TNS8 Eed Mus musculus Q921E6
Anti Tag CoIP
23180766
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04447 EPOP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epop NCBI NCBI:100170841