Suz12 - SUZ12 polycomb repressive complex 2 subunit Gene

Also Known as mKIAA0160; D11Ertd530e; 2610028O16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 52615

Summary

This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Suz12 Products (2)

mRNA Protein Name
NM_001163018.1 NP_001156490.1 polycomb protein Suz12 isoform 2
NM_199196.2 NP_954666.1 polycomb protein Suz12 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IPI
IPI: Inferred from physical interaction
22911650 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24268575 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
18483221 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16687444 MGI
enables lncRNA binding IPI
IPI: Inferred from physical interaction
28041882 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
22770845 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20064375 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20956546 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15385962 MGI
acts upstream of or within chromatin organization IMP
IMP: Inferred from mutant phenotype
16359901 MGI
involved in facultative heterochromatin formation IDA
IDA: Inferred from direct assay
20064375 MGI
acts upstream of or within gene expression IGI
IGI: Inferred from genetic interaction
28041882 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16687444 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
28041882 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15385962 MGI
acts upstream of or within random inactivation of X chromosome IMP
IMP: Inferred from mutant phenotype
27892467 MGI
Cellular Component GO Annotation Evidence References Source
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
20064375 MGI
part of chromatin silencing complex IDA
IDA: Inferred from direct assay
26658965 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18483221 MGI
part of protein-DNA complex IDA
IDA: Inferred from direct assay
18483221 MGI
part of ribonucleoprotein complex IPI
IPI: Inferred from physical interaction
28041882 MGI
located in sex chromatin IDA
IDA: Inferred from direct assay
15525528 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polycomb protein Suz12

  • suppressor of zeste 12 homolog

  • suppressor of zeste 12 protein homolog

Suz12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Suz12 Q80U70 Jarid2 Mus musculus Q62315
Anti Bait CoIP
20064376
Intra
Suz12 Q80U70 Jarid2 Mus musculus Q62315
Anti Bait CoIP
20064375
Intra
Suz12 Q80U70 Jarid2 Mus musculus Q62315
Pull Down
20064375
Intra
Suz12 Q80U70 Ezh2 Mus musculus Q6AXH7
Pull Down
23624931
Intra
Suz12 Q80U70 Ezh2 Mus musculus Q61188
Anti Bait CoIP
24074865
Intra
Suz12 Q80U70 Ezh2 Mus musculus Q61188
Anti Bait CoIP
20064375
Intra
Suz12 Q80U70 Ezh2 Mus musculus Q61188
Anti Bait CoIP
20064376
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130708 UNC6852 Inhibitor 98.49% Unkown
HY-101512 A-395 Inhibitor 99.12% Unkown
HY-148334 MS8815 Degrader 99.95% Unkown
HY-W014099 Boc-NH-C4-acid 99.65% Unkown
HY-130638 (S,R,S)-AHPC-O-Ph-PEG1-NH-Boc / Unkown
HY-101512D rel-A-395 hydrochloride Inhibitor / Unkown
HY-130637 Boc-NH-PEG1-Ph-O-CH2COOH / Unkown
HY-168131 PROTAC EZH2 Degrader-3 / Unkown
HY-174372 EZH2-IN-23 Inhibitor / Unkown
HY-181308 PROTAC EZH2 Degrader-13 Degrader / Unkown
HY-181320 PROTAC EZH2 Degrader-19 Degrader / Unkown
HY-181323 PROTAC EZH2 Degrader-22 Degrader / Unkown
HY-181392 PROTAC EZH2 Degrader-35 Degrader / Unkown
HY-181413 PROTAC EZH2 Degrader-44 / Unkown
HY-RS14053 SUZ12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17149 Suz12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23598 Suz12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Suz12 NCBI NCBI:23512