Ezh2 - enhancer of zeste 2 polycomb repressive complex 2 subunit Gene

Also Known as KMT6; Enx-1; Enx1h; mKIAA4065

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14056

About Ezh2

Chromosome 6: 47,507,073-47,572,275 reverse strand.GRCm39:CM000999.3

This gene has 15 transcripts (splice variants), 237 orthologues, 20 paralogues and is associated with 24 phenotypes. Biased expression in CNS E11.5 (RPKM 46.4), CNS E14 (RPKM 3.5) and 11 other tissues.

Summary

Enables several functions, including nucleic acid binding activity; protein methyltransferase activity; and transcription corepressor activity. Involved in B cell differentiation; cell development; and regulation of circadian rhythm. Acts upstream of or within several processes, including macromolecule methylation; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Located in pericentric heterochromatin and pronucleus. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome; bone Cancer (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung Cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ezh2 Products (48)

mRNA Protein Name
NM_001409815.1 NP_001396744.1 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001409818.1 NP_001396747.1 histone-lysine N-methyltransferase EZH2 isoform 4
NM_001409813.1 NP_001396742.1 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001146689.1 NP_001140161.1 histone-lysine N-methyltransferase EZH2 isoform 2
NM_001409828.1 NP_001396757.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409819.1 NP_001396748.1 histone-lysine N-methyltransferase EZH2 isoform 4
NM_001409810.1 NP_001396739.1 histone-lysine N-methyltransferase EZH2 isoform 3
NM_001409826.1 NP_001396755.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_007971.2 NP_031997.2 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001409814.1 NP_001396743.1 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001409823.1 NP_001396752.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409816.1 NP_001396745.1 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001409831.1 NP_001396760.1 histone-lysine N-methyltransferase EZH2 isoform 9
NM_001409817.1 NP_001396746.1 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001409829.1 NP_001396758.1 histone-lysine N-methyltransferase EZH2 isoform 7
NM_001409825.1 NP_001396754.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409822.1 NP_001396751.1 histone-lysine N-methyltransferase EZH2 isoform 5
NM_001409824.1 NP_001396753.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409820.1 NP_001396749.1 histone-lysine N-methyltransferase EZH2 isoform 4
NM_001409827.1 NP_001396756.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409812.1 NP_001396741.1 histone-lysine N-methyltransferase EZH2 isoform 3
NM_001409830.1 NP_001396759.1 histone-lysine N-methyltransferase EZH2 isoform 8
NM_001409811.1 NP_001396740.1 histone-lysine N-methyltransferase EZH2 isoform 3
NM_001409821.1 NP_001396750.1 histone-lysine N-methyltransferase EZH2 isoform 4
NM_001146689.1 NP_001140161.1 histone-lysine N-methyltransferase EZH2 isoform 2
NM_001409810.1 NP_001396739.1 histone-lysine N-methyltransferase EZH2 isoform 3
NM_001409811.1 NP_001396740.1 histone-lysine N-methyltransferase EZH2 isoform 3
NM_001409812.1 NP_001396741.1 histone-lysine N-methyltransferase EZH2 isoform 3
NM_001409813.1 NP_001396742.1 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001409814.1 NP_001396743.1 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001409815.1 NP_001396744.1 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001409816.1 NP_001396745.1 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001409817.1 NP_001396746.1 histone-lysine N-methyltransferase EZH2 isoform 1
NM_001409818.1 NP_001396747.1 histone-lysine N-methyltransferase EZH2 isoform 4
NM_001409819.1 NP_001396748.1 histone-lysine N-methyltransferase EZH2 isoform 4
NM_001409820.1 NP_001396749.1 histone-lysine N-methyltransferase EZH2 isoform 4
NM_001409821.1 NP_001396750.1 histone-lysine N-methyltransferase EZH2 isoform 4
NM_001409822.1 NP_001396751.1 histone-lysine N-methyltransferase EZH2 isoform 5
NM_001409823.1 NP_001396752.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409824.1 NP_001396753.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409825.1 NP_001396754.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409826.1 NP_001396755.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409827.1 NP_001396756.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409828.1 NP_001396757.1 histone-lysine N-methyltransferase EZH2 isoform 6
NM_001409829.1 NP_001396758.1 histone-lysine N-methyltransferase EZH2 isoform 7
NM_001409830.1 NP_001396759.1 histone-lysine N-methyltransferase EZH2 isoform 8
NM_001409831.1 NP_001396760.1 histone-lysine N-methyltransferase EZH2 isoform 9
NM_007971.2 NP_031997.2 histone-lysine N-methyltransferase EZH2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
23942234 MGI
enables RNA binding IDA
IDA: Inferred from direct assay
21936910 MGI
enables RNA binding IPI
IPI: Inferred from physical interaction
21123648 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24137001 MGI
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20798045 MGI
enables RNA polymerase II core promoter sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
16717091 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
18483221 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15520282 MGI
enables histone H3K27 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
16717091 MGI
enables histone methyltransferase activity IDA
IDA: Inferred from direct assay
12900441 MGI
enables lncRNA binding IDA
IDA: Inferred from direct assay
27618650 MGI
enables primary miRNA binding IDA
IDA: Inferred from direct assay
24137001 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9584197 MGI
enables protein-lysine N-methyltransferase activity IDA
IDA: Inferred from direct assay
25547114 MGI
enables ribonucleoprotein complex binding IDA
IDA: Inferred from direct assay
21172659 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20956546 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
19026781 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
23531880 MGI
acts upstream of or within DNA methylation-dependent heterochromatin formation IMP
IMP: Inferred from mutant phenotype
24105743 MGI
acts upstream of or within G1 to G0 transition IMP
IMP: Inferred from mutant phenotype
19303854 MGI
acts upstream of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
19303854 MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress IDA
IDA: Inferred from direct assay
24137001 MGI
acts upstream of or within cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
20808772 MGI
acts upstream of or within cellular response to trichostatin A IMP
IMP: Inferred from mutant phenotype
24137001 MGI
acts upstream of or within cerebellar cortex development IMP
IMP: Inferred from mutant phenotype
20798045 MGI
acts upstream of epidermal cell differentiation IMP
IMP: Inferred from mutant phenotype
19303854 MGI
involved in facultative heterochromatin formation IDA
IDA: Inferred from direct assay
20064375 MGI
involved in hemopoiesis IMP
IMP: Inferred from mutant phenotype
23531880 MGI
acts upstream of or within hepatocyte homeostasis IGI
IGI: Inferred from genetic interaction
25477280 MGI
acts upstream of keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
19303854 MGI
acts upstream of or within liver regeneration IGI
IGI: Inferred from genetic interaction
25477280 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IGI
IGI: Inferred from genetic interaction
25547114 MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
19303854 MGI
acts upstream of or within negative regulation of epidermal cell differentiation IMP
IMP: Inferred from mutant phenotype
19303854 MGI
acts upstream of or within negative regulation of keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
19303854 MGI
acts upstream of or within negative regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
19303854 MGI
acts upstream of or within negative regulation of striated muscle cell differentiation IDA
IDA: Inferred from direct assay
15520282 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24105743 MGI
acts upstream of or within negative regulation of transcription elongation by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19303854 MGI
acts upstream of or within protein localization to chromatin IMP
IMP: Inferred from mutant phenotype
18311137 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19303854 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
16717091 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20798045 MGI
acts upstream of or within regulation of gliogenesis IMP
IMP: Inferred from mutant phenotype
20798045 MGI
acts upstream of or within regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
20798045 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19303854 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21498568 MGI
acts upstream of or within response to tetrachloromethane IGI
IGI: Inferred from genetic interaction
25477280 MGI
acts upstream of or within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IMP
IMP: Inferred from mutant phenotype
21498568 MGI
acts upstream of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
19303854 MGI
Cellular Component GO Annotation Evidence References Source
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
19026781 MGI
part of chromatin silencing complex IDA
IDA: Inferred from direct assay
26658965 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
23046516 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9584197 MGI
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
27892467 MGI
located in pronucleus IDA
IDA: Inferred from direct assay
12900441 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ezh2 Protein Structure

EZH2_WD-Binding

EZH2_WD-Binding: pfam11616 (38 - 67)

PRC2_HTH_1

PRC2_HTH_1: pfam18118 (157 - 248)

preSET_CXC

preSET_CXC: pfam18264 (558 - 589)

SET_EZH2

SET_EZH2: cd19218 (608 - 727)

  • 0
  • 200
  • 400
  • 600
  • 746 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EZH2

  • enhancer of zeste homolog 2

Ezh2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ezh2 Q6AXH7 Suz12 Mus musculus Q80U70
Anti Bait CoIP
23624931
Intra
Ezh2 Q6AXH7 Suz12 Mus musculus Q80U70
Pull Down
23624931
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13803 Tazemetostat Inhibitor 99.93% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-145602 Tulmimetostat Inhibitor 99.79% Phase 2
HY-13470 GSK126 Inhibitor 99.98% Phase 1

Pre-clinical Phase

Bioactive Molecules (78)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13500 GSK343 Inhibitor 99.85% Unkown
HY-10442 3-Deazaneplanocin A Inhibitor 99.97% Unkown
HY-12186 3-Deazaneplanocin A hydrochloride Inhibitor 99.98% Unkown
HY-15646 UNC1999 Inhibitor 99.87% Unkown
HY-133129 MS1943 Inhibitor 98.92% Unkown
HY-148333 MS177 Inhibitor 99.55% Unkown
HY-130708 UNC6852 Inhibitor 98.49% Unkown
HY-101512 A-395 Inhibitor 99.12% Unkown
HY-147525 PROTAC EZH2 Degrader-1 Inhibitor 99.44% Unkown
HY-162250 MS8847 Inhibitor 99.78% Unkown
HY-103682 PF-06726304 Inhibitor 99.71% Unkown
HY-16986 EPZ011989 Inhibitor 98.75% Unkown
HY-N5024 Gambogenic acid Inhibitor 99.91% Unkown
HY-148334 MS8815 Degrader 99.95% Unkown
HY-15555 EPZ005687 Inhibitor 99.46% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-157844 NUCC-0226272 Degrader 99.68% Unkown
HY-78694 5-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide Ligand 98.22% Unkown
HY-100846 JQEZ5 Inhibitor 98.14% Unkown
HY-12856 GSK503 Inhibitor 99.52% Unkown
HY-157164 PROTAC EZH2 Degrader-2 Degrader 98.77% Unkown
HY-15573 EI1 Inhibitor 98.84% Unkown
HY-147090 Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH Degrader 99.06% Unkown
HY-162384 EPIC-0628 Inhibitor 98.66% Unkown
HY-144330 TDI-6118 Inhibitor 99.08% Unkown
HY-A0298 EZH2-IN-2 Inhibitor 98.51% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-101508 GNA002 Inhibitor 98.02% Unkown
HY-146999 YM458 Inhibitor 99.16% Unkown
HY-131246 DM-01 Inhibitor 98.05% Unkown
HY-176165 CDK9/EZH2-IN-1 Inhibitor 99.08% Unkown
HY-119198 NSC745885 Inhibitor 98.0% Unkown
HY-147230 EZH2-IN-13 Inhibitor 99.72% Unkown
HY-111418 EBI-2511 Inhibitor 98.67% Unkown
HY-136188 UNC2399 Inhibitor 99.16% Unkown
HY-122936 Tanshindiol C Inhibitor 98.47% Unkown
HY-16986A EPZ011989 trifluoroacetate Inhibitor 98.71% Unkown
HY-144881 (S)-HH2853 Inhibitor / Unkown
HY-144882 (R)-HH2853 Inhibitor / Unkown
HY-134899 CPI-1328 Inhibitor / Unkown
HY-12186G 3-Deazaneplanocin A hydrochloride (GMP) Inhibitor / Unkown
HY-103682A PF-06726304 acetate Inhibitor / Unkown
HY-168131 PROTAC EZH2 Degrader-3 Degrader / Unkown
HY-178694 DC-PRC2in-01 Inhibitor / Unkown
HY-177497 SKLB-03220 Inhibitor / Unkown
HY-156292 IHMT-EZH2-426 Inhibitor / Unkown
HY-179351 EZH2 ligand-1 Ligand / Unkown
HY-179500 EZH2 ligand-Linker Conjugate 1 / Unkown
HY-149463 EZH2-IN-16 Inhibitor / Unkown
HY-163741 EZH2-IN-19 Inhibitor / Unkown
HY-181157 T/E PPI-IN-1 Inhibitor / Unkown
HY-181413 PROTAC EZH2 Degrader-44 Degrader / Unkown
HY-163288 EZH2/HSP90-IN-29 Inhibitor / Unkown
HY-143616 EZH2-IN-7 Inhibitor / Unkown
HY-179386 PARP1/EZH2-IN-1 Inhibitor / Unkown
HY-181327 PROTAC EZH2 Degrader-26 Degrader / Unkown
HY-122640 NPD13668 Inhibitor / Unkown
HY-179499 PROTAC EZH2 Degrader-9 Degrader / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-181308 PROTAC EZH2 Degrader-13 Degrader / Unkown
HY-169400 HDACs/EZH2-IN-1 Inhibitor / Unkown
HY-181331 PROTAC EZH2 Degrader-27 Inhibitor / Unkown
HY-162601 D-01 Inhibitor / Unkown
HY-184270 YM1240 Inhibitor / Unkown
HY-181319 PROTAC EZH2 Degrader-21 Degrader / Unkown
HY-181333 PROTAC EZH2 Degrader-38 Degrader / Unkown
HY-161083 PARP/EZH2-IN-2 Inhibitor / Unkown
HY-W1063360 EZH2 ligand-5 Ligand / Unkown
HY-141566 EZH2-IN-5 Inhibitor / Unkown
HY-139150 EZH2-IN-4 Inhibitor / Unkown
HY-181393 EZH2 ligand-3 Ligand / Unkown
HY-154854 BBDDL2059 Inhibitor / Unkown
HY-160423 MS8815N Control / Unkown
HY-181410 PROTAC EZH2 Degrader-41 / Unkown
HY-169958 EZH2-IN-22 Inhibitor / Unkown
HY-185582 EZH2 ligand-4 / Unkown
HY-116605 GSK926 Inhibitor / Unkown
HY-122115 DCE_42 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ezh2 NCBI NCBI:2146