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Cat. No.: HY-144882

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(R)-HH2853

(R)-HH2853 is a mutant EZH2 inhibitor with an IC₅₀ of <100 nM for EZH2-Y641F. (R)-HH2853 can be used for cancer and autoimmune diseases (WO2018045971A1; compound 201).

For research use only. We do not sell to patients.

CAS No.: 2202678-06-4
Formula: C₃₁H₃₆F₃N₇O₃
Molecular Weight:611.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(R)-HH2853 Chemical Structure

CAS No.: 2202678-06-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(R)-HH2853 is a mutant EZH2 inhibitor with an IC₅₀ of <100 nM for EZH2-Y641F. (R)-HH2853 can be used for cancer and autoimmune diseases (WO2018045971A1; compound 201)^[1].

IC₅₀ & Target^[1]

EZH2 Y641F mutant type

<100 nM (IC₅₀)

All Histone Methyltransferase Isoforms :

Chemical Information

CAS No. 2202678-06-4
Molecular Weight 611.66
Formula C₃₁H₃₆F₃N₇O₃
SMILES

C[C@@H](N1CCN(CC1)CC(F)(F)F)C2=C(C)C(C(NCC3=C(C=C(NC3=O)C)OC)=O)=CC4=C(C5=CC=C(N=N5)C)C=CN24
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xuxing Chen, et al. Pyrido five-element aromatic ring compound, preparation method therefor and use thereof. WO2018045971A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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(R)-HH2853

High-Throughput Bioactive Compound Library

All Histone Methyltransferase Isoforms