EZH2 - enhancer of zeste 2 polycomb repressive complex 2 subunit Gene

Also Known as WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2146

About EZH2

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:148,807,383-148,884,291 (from NCBI)

This gene has 20 transcripts (splice variants), 237 orthologues, 19 paralogues and is associated with 118 phenotypes. Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.6) and 14 other tissues.

Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

EZH2 Products (43)

mRNA	Protein	Name
XM_047420000.1	XP_047275956.1	histone-lysine N-methyltransferase EZH2 isoform X19
XM_011515894.3	XP_011514196.1	histone-lysine N-methyltransferase EZH2 isoform X15
XM_011515893.3	XP_011514195.1	histone-lysine N-methyltransferase EZH2 isoform X14
XM_047420008.1	XP_047275964.1	histone-lysine N-methyltransferase EZH2 isoform X29
XM_011515895.3	XP_011514197.1	histone-lysine N-methyltransferase EZH2 isoform X17
XM_011515892.3	XP_011514194.1	histone-lysine N-methyltransferase EZH2 isoform X13
XM_005249964.5	XP_005250021.1	histone-lysine N-methyltransferase EZH2 isoform X22
NM_001203247.2	NP_001190176.1	histone-lysine N-methyltransferase EZH2 isoform c
NM_001203249.2	NP_001190178.1	histone-lysine N-methyltransferase EZH2 isoform e
XM_011515887.4	XP_011514189.1	histone-lysine N-methyltransferase EZH2 isoform X8
XM_011515896.3	XP_011514198.1	histone-lysine N-methyltransferase EZH2 isoform X24
XM_047419989.1	XP_047275945.1	histone-lysine N-methyltransferase EZH2 isoform X1
XM_047419997.1	XP_047275953.1	histone-lysine N-methyltransferase EZH2 isoform X10
XM_011515901.4	XP_011514203.1	histone-lysine N-methyltransferase EZH2 isoform X29
XM_047420002.1	XP_047275958.1	histone-lysine N-methyltransferase EZH2 isoform X23
XM_047420001.1	XP_047275957.1	histone-lysine N-methyltransferase EZH2 isoform X20
NM_001203248.2	NP_001190177.1	histone-lysine N-methyltransferase EZH2 isoform d
XM_011515883.3	XP_011514185.1	histone-lysine N-methyltransferase EZH2 isoform X1
XM_011515885.3	XP_011514187.1	histone-lysine N-methyltransferase EZH2 isoform X4
XM_047420009.1	XP_047275965.1	histone-lysine N-methyltransferase EZH2 isoform X30
XM_017011817.3	XP_016867306.1	histone-lysine N-methyltransferase EZH2 isoform X1
XM_047419993.1	XP_047275949.1	histone-lysine N-methyltransferase EZH2 isoform X6
NM_004456.5	NP_004447.2	histone-lysine N-methyltransferase EZH2 isoform a
XM_047419995.1	XP_047275951.1	histone-lysine N-methyltransferase EZH2 isoform X7
XM_047419999.1	XP_047275955.1	histone-lysine N-methyltransferase EZH2 isoform X18
XM_017011819.2	XP_016867308.1	histone-lysine N-methyltransferase EZH2 isoform X16
XM_047419994.1	XP_047275950.1	histone-lysine N-methyltransferase EZH2 isoform X6
XM_047419990.1	XP_047275946.1	histone-lysine N-methyltransferase EZH2 isoform X2
XM_017011820.3	XP_016867309.1	histone-lysine N-methyltransferase EZH2 isoform X21
XM_047419991.1	XP_047275947.1	histone-lysine N-methyltransferase EZH2 isoform X3
NM_152998.3	NP_694543.1	histone-lysine N-methyltransferase EZH2 isoform b
XM_005249962.5	XP_005250019.1	histone-lysine N-methyltransferase EZH2 isoform X2
XM_047420006.1	XP_047275962.1	histone-lysine N-methyltransferase EZH2 isoform X26
XM_047420007.1	XP_047275963.1	histone-lysine N-methyltransferase EZH2 isoform X28
XM_047419998.1	XP_047275954.1	histone-lysine N-methyltransferase EZH2 isoform X14
XM_047419996.1	XP_047275952.1	histone-lysine N-methyltransferase EZH2 isoform X9
XM_047420004.1	XP_047275960.1	histone-lysine N-methyltransferase EZH2 isoform X25
XM_011515899.4	XP_011514201.1	histone-lysine N-methyltransferase EZH2 isoform X27
XM_005249963.5	XP_005250020.1	histone-lysine N-methyltransferase EZH2 isoform X6
XM_047420005.1	XP_047275961.1	histone-lysine N-methyltransferase EZH2 isoform X26
XM_011515889.3	XP_011514191.1	histone-lysine N-methyltransferase EZH2 isoform X11
XM_011515890.3	XP_011514192.1	histone-lysine N-methyltransferase EZH2 isoform X12
XM_047419992.1	XP_047275948.1	histone-lysine N-methyltransferase EZH2 isoform X5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	EXP EXP: Inferred from Experiment	35682829	GOA
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	19734898	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	20154697	GOA
enables histone H3K27 methyltransferase activity	IDA IDA: Inferred from direct assay	15385962	GOA
enables histone H3K27 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	28229514	GOA
enables histone binding	IDA IDA: Inferred from direct assay	33479123	GOA
enables histone methyltransferase activity	IMP IMP: Inferred from mutant phenotype	26694085	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	33479123	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	24623306	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11571280	GOA
enables protein-lysine N-methyltransferase activity	IDA IDA: Inferred from direct assay	19144645	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	29628311	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16179254	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	20154697	GOA
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	24623306	GOA
involved in negative regulation of retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16179254	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20154697	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	20154697	GOA
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	20154697	GOA
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	18713946	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	35609316	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18713946	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	20154697	GOA
involved in positive regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	20154697	GOA
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	16717091	GOA
involved in regulatory ncRNA-mediated heterochromatin formation	IGI IGI: Inferred from genetic interaction	23435381	GOA
involved in subtelomeric heterochromatin formation	IGI IGI: Inferred from genetic interaction	9214638	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	15385962	GOA
located in chromatin	IDA IDA: Inferred from direct assay	19734898	GOA
is active in chromosome	IDA IDA: Inferred from direct assay	19734898	GOA
located in chromosome, telomeric region	IGI IGI: Inferred from genetic interaction	9214638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19144645	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EZH2 Protein Structure

EZH2_WD-Binding

SET

0
200
400
600
751 a.a.

Protein Preferred Names	Protein Names
histone-lysine N-methyltransferase EZH2	enhancer of zeste homolog 2 lysine N-methyltransferase 6

EZH2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Bait CoIP	24183680
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Tag CoIP	26496610
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	TAP	27705803
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Bait CoIP	20075857
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Tag CoIP	33961781
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	CH-IP	23238014
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Tag CoIP	34591612
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Tag CoIP	20543829
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Bait CoIP	23684459
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Bait CoIP	37553330
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Bait CoIP	27728805
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Bait CoIP	19734898
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Bait CoIP	22439931
Intra	EZH2	Q15910	SUZ12	Homo sapiens	Q15022	Anti Bait CoIP	23079660
Intra	EZH2	Q15910	JARID2	Homo sapiens	Q92833-1	Anti Bait CoIP	20075857
Intra	EZH2	Q15910	JARID2	Homo sapiens	Q92833-1	Anti Tag CoIP	20075857
Intra	EZH2	Q15910	ASXL1	Homo sapiens	Q8IXJ9	Anti Bait CoIP	22897849
Cross	EZH2	Q15910	Dnmt3l	Mus musculus	Q9CWR8	Anti Bait CoIP	24074865
Intra	EZH2	Q15910	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	23455924
Intra	EZH2	Q15910	STAT3	Homo sapiens	P40763	Anti Bait CoIP	23684459
Intra	EZH2	Q15910	PHF1	Homo sapiens	O43189	Anti Tag CoIP	26496610
Intra	EZH2	Q15910	PHF1	Homo sapiens	O43189	TAP	27705803
Intra	EZH2	Q15910	PHF1	Homo sapiens	O43189	Anti Tag CoIP	33961781
Intra	EZH2	Q15910	PHF1	Homo sapiens	O43189	Anti Tag CoIP	34591612
Intra	EZH2	Q15910	DNMT1	Homo sapiens	P26358	Pull Down	16357870
Intra	EZH2	Q15910	DNMT1	Homo sapiens	P26358	Anti Tag CoIP	22094255
Intra	EZH2	Q15910	DNMT1	Homo sapiens	P26358	Anti Bait CoIP	16357870
Intra	EZH2	Q15910	CEP63	Homo sapiens	Q96MT8	Validated Y2H	25416956
Intra	EZH2	Q15910	DNMT3B	Homo sapiens	Q9UBC3	Anti Bait CoIP	24074865
Intra	EZH2	Q15910	DNMT3B	Homo sapiens	Q9UBC3	Anti Bait CoIP	27728808
Intra	EZH2	Q15910	DNMT3B	Homo sapiens	Q9UBC3	Anti Bait CoIP	16357870
Intra	EZH2	Q15910	PML-RAR	Homo sapiens	Q15156	Anti Bait CoIP	17560333
Intra	EZH2	Q15910	PML-RAR	Homo sapiens	Q15156	Anti Tag CoIP	17560333
Intra	EZH2	Q15910	DNMT3A	Homo sapiens	Q9Y6K1	Anti Bait CoIP	16357870
Intra	EZH2	Q15910	DNMT3A	Homo sapiens	Q9Y6K1	Pull Down	16357870
Intra	EZH2	Q15910	DNMT3A	Homo sapiens	Q9Y6K1	Anti Bait CoIP	24074865
Intra	EZH2	Q15910	EED	Homo sapiens	O75530	Anti Tag CoIP	26496610
Intra	EZH2	Q15910	EED	Homo sapiens	O75530	Anti Tag CoIP	34591612
Intra	EZH2	Q15910	EED	Homo sapiens	O75530	Anti Tag CoIP	22094255
Intra	EZH2	Q15910	EED	Homo sapiens	O75530	Anti Bait CoIP	22897849
Intra	EZH2	Q15910	EED	Homo sapiens	O75530	Anti Bait CoIP	22439931
Intra	EZH2	Q15910	EED	Homo sapiens	O75530	Anti Tag CoIP	33961781
Intra	EZH2	Q15910	EED	Homo sapiens	O75530	TAP	27705803
Intra	EZH2	Q15910	EED	Homo sapiens	O75530	TAP	24981860
Intra	EZH2	Q15910	FOXP3	Homo sapiens	Q9BZS1	Anti Bait CoIP	30510991
Intra	EZH2	Q15910	FOXP3	Homo sapiens	Q9BZS1	Anti Tag CoIP	30510991
Intra	EZH2	Q15910	FOXP3	Homo sapiens	Q9BZS1	PLA	30510991

Cross: Cross-species interaction Intra: Intraspecies interaction

EZH2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80507	KMT6/EZH2 Antibody (YA320)	IHC-P, ICC/IF	Human
HY-P83287	KMT6/EZH2 Antibody (YA3032)	WB	Human
HY-P83287A	KMT6/EZH2 Antibody (YA3032)(PBS only)	WB	Human
HY-P86229	KMT6/EZH2 Antibody (YA5921)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Tatton-Brown-Rahman Syndrome	TBRS Dnmt3a Overgrowth Syndrome Tatton-Brown-Rahman Overgrowth Syndrome Dos Dnmt3a-Related Overgrowth Syndrome Doid:0112339 Dose
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Rhabdoid Cancer	Rhabdoid Tumor Malignant Rhabdoid Tumor Malignant Rhabdoid Tumour Rhabdoid Sarcoma Rhabdoid Tumor Predisposition Syndrome 1 Rhabdoid Tumor Predisposition Syndrome 2 Atypical Teratoid Rhabdoid Tumor Brain Tumor, Posterior Fossa, Of Infancy, Familial Atypical Teratoid/Rhabdoid Tumor
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Sotos Syndrome	Cerebral Gigantism SOTOS Chromosome 5q35 Deletion Syndrome Sotos Syndrome 1, Formerly Sotos1, Formerly Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development Sotos Sequence Sotos' Syndrome Sotos1 Sotos Syndrome 1
Rett Syndrome	Atypical Rett Syndrome RTT Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Atypical Rett Syndrome, Preserved Speech Variant Rett'S Disorder Rett Syndrome Variant Rett Disorder Cerebroatrophic Hyperammonemia Rett Like Syndrome Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Ovarian Clear Cell Carcinoma	Clear-Cell Ovarian Carcinoma
Breast Myoepithelial Carcinoma
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Histone Mutated Tumor	Histone Mutated Tumour
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 CMM1 Melanoma, Cutaneous Malignant Cmm Melanoma, Malignant Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Ezb Diffuse Large B-Cell Lymphoma	Ezb Dlbcl Doid:0081065
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Rhabdomyosarcoma
Primary Hyperoxaluria	Hyperoxaluria, Primary Oxalosis Hyperoxaluria Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Weaver Syndrome	Wss Weaver-Smith Syndrome WVS Weaver-Like Syndrome Weaver-Williams Syndrome Camptodactyly-Overgrowth-Unusual Facies Syndrome Camptodactyly - Overgrowth - Unusual Facies Ezh2 Related Overgrowth Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly Weaver Smith Syndrome Weaver Like Syndrome Weaver Williams Syndrome Camptodactyly-Overgrowth-Unusual Facies Weaver Syndrome 1 Weaver Syndrome 2 Wvs1 Wvs2
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Kabuki Syndrome 1	Kabuki Syndrome Niikawa-Kuroki Syndrome Kabuki Make-Up Syndrome Kms KABUK1 Kabuki Make Up Syndrome Nks Kabuki Makeup Syndrome Kabuki Syndrome, Type 1
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Skin Melanoma	Cutaneous Melanoma Malignant Ear Melanoma Malignant Lip Melanoma Malignant Lower Limb Melanoma Malignant Melanoma Of Ear And/Or External Auricular Canal Malignant Melanoma Of Skin Of Lower Limb Malignant Melanoma Of Skin Of Trunk Except Scrotum Malignant Melanoma Of Skin Of Upper Limb Malignant Neck Melanoma Malignant Scalp Melanoma Malignant Trunk Melanoma Malignant Upper Limb Melanoma Melanoma, Cutaneous Malignant Melanoma Malignant Melanoma Of Skin Melanoma Nos Malignant Mole, Meaning Melanoma Of Unspecified Site Melanoma Of Unspecified Site Cutaneous Malignant Melanoma Mm - [Malignant Melanoma]
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Hyperoxaluria, Primary, Type I	Primary Hyperoxaluria Type 1 HP1 Glycolic Aciduria Alanine-Glyoxylate Aminotransferase Deficiency Hepatic Agt Deficiency Oxalosis I Primary Hyperoxaluria, Type I Serine:Pyruvate Aminotransferase Deficiency Hyperoxaluria, Primary, Type 1 Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency Serine Pyruvate Aminotransferase Deficiency Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Oxalosis 1 Hyperoxaluria Primary 1 Hyperoxaluria Primary Type I Ph1 Primary Hyperoxaluria Type I Oxalosis Type 1 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13803	Tazemetostat	Inhibitor	99.93%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145602	Tulmimetostat	Inhibitor	99.79%	Phase 2
HY-13470	GSK126	Inhibitor	99.98%	Phase 1

Pre-clinical Phase

Bioactive Molecules (78)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13500	GSK343	Inhibitor	99.85%	Unkown
HY-10442	3-Deazaneplanocin A	Inhibitor	99.97%	Unkown
HY-12186	3-Deazaneplanocin A hydrochloride	Inhibitor	99.98%	Unkown
HY-15646	UNC1999	Inhibitor	99.87%	Unkown
HY-133129	MS1943	Inhibitor	98.92%	Unkown
HY-148333	MS177	Inhibitor	99.55%	Unkown
HY-130708	UNC6852	Inhibitor	98.49%	Unkown
HY-101512	A-395	Inhibitor	99.12%	Unkown
HY-147525	PROTAC EZH2 Degrader-1	Inhibitor	99.44%	Unkown
HY-162250	MS8847	Inhibitor	99.78%	Unkown
HY-103682	PF-06726304	Inhibitor	99.71%	Unkown
HY-16986	EPZ011989	Inhibitor	98.75%	Unkown
HY-N5024	Gambogenic acid	Inhibitor	99.91%	Unkown
HY-148334	MS8815	Degrader	99.95%	Unkown
HY-15555	EPZ005687	Inhibitor	99.46%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-157844	NUCC-0226272	Degrader	99.68%	Unkown
HY-78694	5-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide	Ligand	98.22%	Unkown
HY-100846	JQEZ5	Inhibitor	98.14%	Unkown
HY-12856	GSK503	Inhibitor	99.52%	Unkown
HY-157164	PROTAC EZH2 Degrader-2	Degrader	98.77%	Unkown
HY-15573	EI1	Inhibitor	98.84%	Unkown
HY-147090	Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH	Degrader	99.06%	Unkown
HY-162384	EPIC-0628	Inhibitor	98.66%	Unkown
HY-144330	TDI-6118	Inhibitor	99.08%	Unkown
HY-A0298	EZH2-IN-2	Inhibitor	98.51%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown
HY-101508	GNA002	Inhibitor	98.02%	Unkown
HY-146999	YM458	Inhibitor	99.16%	Unkown
HY-131246	DM-01	Inhibitor	98.05%	Unkown
HY-176165	CDK9/EZH2-IN-1	Inhibitor	99.08%	Unkown
HY-119198	NSC745885	Inhibitor	98.0%	Unkown
HY-147230	EZH2-IN-13	Inhibitor	99.72%	Unkown
HY-111418	EBI-2511	Inhibitor	98.67%	Unkown
HY-136188	UNC2399	Inhibitor	99.16%	Unkown
HY-122936	Tanshindiol C	Inhibitor	98.47%	Unkown
HY-16986A	EPZ011989 trifluoroacetate	Inhibitor	98.71%	Unkown
HY-144881	(S)-HH2853	Inhibitor	/	Unkown
HY-144882	(R)-HH2853	Inhibitor	/	Unkown
HY-134899	CPI-1328	Inhibitor	/	Unkown
HY-12186G	3-Deazaneplanocin A hydrochloride (GMP)	Inhibitor	/	Unkown
HY-103682A	PF-06726304 acetate	Inhibitor	/	Unkown
HY-168131	PROTAC EZH2 Degrader-3	Degrader	/	Unkown
HY-178694	DC-PRC2in-01	Inhibitor	/	Unkown
HY-177497	SKLB-03220	Inhibitor	/	Unkown
HY-156292	IHMT-EZH2-426	Inhibitor	/	Unkown
HY-179500	EZH2 ligand-Linker Conjugate 1		/	Unkown
HY-179351	EZH2 ligand-1	Ligand	/	Unkown
HY-163741	EZH2-IN-19	Inhibitor	/	Unkown
HY-149463	EZH2-IN-16	Inhibitor	/	Unkown
HY-181157	T/E PPI-IN-1	Inhibitor	/	Unkown
HY-163288	EZH2/HSP90-IN-29	Inhibitor	/	Unkown
HY-181413	PROTAC EZH2 Degrader-44	Degrader	/	Unkown
HY-143616	EZH2-IN-7	Inhibitor	/	Unkown
HY-179386	PARP1/EZH2-IN-1	Inhibitor	/	Unkown
HY-181327	PROTAC EZH2 Degrader-26	Degrader	/	Unkown
HY-122640	NPD13668	Inhibitor	/	Unkown
HY-179499	PROTAC EZH2 Degrader-9	Degrader	/	Unkown
HY-132885	PARP/EZH2-IN-1	Inhibitor	/	Unkown
HY-181308	PROTAC EZH2 Degrader-13	Degrader	/	Unkown
HY-169400	HDACs/EZH2-IN-1	Inhibitor	/	Unkown
HY-181331	PROTAC EZH2 Degrader-27	Inhibitor	/	Unkown
HY-162601	D-01	Inhibitor	/	Unkown
HY-184270	YM1240	Inhibitor	/	Unkown
HY-181319	PROTAC EZH2 Degrader-21	Degrader	/	Unkown
HY-181333	PROTAC EZH2 Degrader-38	Degrader	/	Unkown
HY-161083	PARP/EZH2-IN-2	Inhibitor	/	Unkown
HY-W1063360	EZH2 ligand-5	Ligand	/	Unkown
HY-139150	EZH2-IN-4	Inhibitor	/	Unkown
HY-141566	EZH2-IN-5	Inhibitor	/	Unkown
HY-181393	EZH2 ligand-3	Ligand	/	Unkown
HY-154854	BBDDL2059	Inhibitor	/	Unkown
HY-160423	MS8815N	Control	/	Unkown
HY-181410	PROTAC EZH2 Degrader-41		/	Unkown
HY-169958	EZH2-IN-22	Inhibitor	/	Unkown
HY-185582	EZH2 ligand-4		/	Unkown
HY-116605	GSK926	Inhibitor	/	Unkown
HY-122115	DCE_42	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EZH2	VGNC	VGNC:62018
Rattus norvegicus	EZH2	RGD	RGD:1595860
Mus musculus	EZH2	MGD	MGI:107940
Canis familiaris	EZH2	VGNC	VGNC:40541
Macaca mulatta	EZH2	VGNC	VGNC:72458
Bos taurus	EZH2	VGNC	VGNC:28675
Others	EZH2	NCBI