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EBI-2511 

Cat. No.: HY-111418
Handling Instructions

EBI-2511 is a highly potent and orally active EZH2 inhibitor, with an IC50 of 6 nM in Pfeffiera cell lines, respectively.

For research use only. We do not sell to patients.

EBI-2511 Chemical Structure

EBI-2511 Chemical Structure

CAS No. : 2098546-05-3

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

EBI-2511 is a highly potent and orally active EZH2 inhibitor, with an IC50 of 6 nM in Pfeffiera cell lines, respectively.

IC50 & Target

IC50: 6 nM (EZH2)[1].

In Vitro

EBI-2511 (Compound 34) significantly reduces cellular H3K27me3 levels in a dose-dependent manner with an approximate IC50 of 8 nM, which is 3-fold more potent than EPZ-6438. In addition to Pfeffier cell line, EBI-2511 was shown active with IC50 value of 55 nM against WSU-DLCL2[1].

In Vivo

EBI-2511 displays a dose-dependent inhibition on the tumor growth, resulting in 28% (10mg/kg), 83% (30mg/kg), and 97% (100mg/kg) reduction in tumor size. At the same dosage level, EBI-2511 shows a superior anti-tumor efficacy to EPZ-6438 (P<0.01). It is noteworthy that no significant changes in body weights of all treatment groups are observed[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7338 mL 8.6690 mL 17.3379 mL
5 mM 0.3468 mL 1.7338 mL 3.4676 mL
10 mM 0.1734 mL 0.8669 mL 1.7338 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

576.77

Formula

C₃₄H₄₈N₄O₄

CAS No.

2098546-05-3

SMILES

CCC1=C(C(NCC2=C(C)C=C(C)NC2=O)=O)C(C=C(C3CCN(C(C)C)CC3)O4)=C4C=C1N(C5CCOCC5)CC

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
EBI-2511
Cat. No.:
HY-111418
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EBI-2511

Cat. No.: HY-111418