EZH2-IN-22
EZH2-IN-22 (example 92) is a potent EZH2 inhibitor with IC50 values of <0.00051, <0.00051, 0.00052 µM for EZH2 (Y641N), EZH2 (Y641F), EZH2 (wt), respectively. EZH2-IN-22 shows antiproliferation activity.
For research use only. We do not sell to patients.
- CAS No.: 2766231-05-2
- Formula: C36H50N4O8
- Molecular Weight:666.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
EZH2 Y641N <0.00051 μM (IC50) |
EZH2 Y641F mutant type <0.00051 μM (IC50) |
EZH2 WT 0.00052 μM (IC50) |
Chemical Information
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CAS No. 2766231-05-2
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Molecular Weight 666.80
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Formula C36H50N4O8
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SMILES
OC(/C=C\C(O)=O)=O.CCN(C1CCOCC1)C2=C(C(C(NCC3=C(C=C(NC3=O)C)C)=O)=CC(O[C@@H]4C[C@@H](N5CCCCC5)C4)=C2)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EZH2-IN-22 Related Classifications
HY-169958 Related Classifications
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