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Cat. No.: HY-185582

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EZH2 ligand-4

EZH2 ligand-4 (Precursor 1) is a ligand for the target protein for PROTAC (EZH2). EZH2 ligand-4 can be used to synthesize MS8847 (HY-162250).

For research use only. We do not sell to patients.

CAS No.: 3050872-19-7
Formula: C₃₇H₄₉N₅O₅
Molecular Weight:643.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EZH2 ligand-4 Chemical Structure

CAS No.: 3050872-19-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

EZH2 ligand-4 (Precursor 1) is a ligand for the target protein for PROTAC (EZH2). EZH2 ligand-4 can be used to synthesize MS8847 (HY-162250)^[1].

IC₅₀ & Target^[1]

EZH2

All Histone Methyltransferase Isoforms :

Chemical Information

CAS No. 3050872-19-7
Molecular Weight 643.82
Formula C₃₇H₄₉N₅O₅
SMILES

O=C(CCN1CCN(CC1)CC2=CC=C(C3=CC(N(C4CCOCC4)CC)=C(C)C(C(NCC5=C(C=C(NC5=O)C)C)=O)=C3)C=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Velez J, et al. Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2. Eur J Med Chem. 2024;267:116154. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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