1. Epigenetics
  2. Histone Methyltransferase
  3. DM-01

DM-01 

Cat. No.: HY-131246 Purity: 98.03%
Handling Instructions

DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors.

For research use only. We do not sell to patients.

DM-01 Chemical Structure

DM-01 Chemical Structure

CAS No. : 2355280-00-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors[1].

IC50 & Target[1]

EZH2

 

In Vitro

Knockdown EZH2 in A549 cells results in the decrease of cell sensitivity to DM-01 at 50 and 100 μM concentrations. DM-01 also shows comparable inhibitory activity for K562 cells with an IC50 value of 58.706 μΜ[1].
DM-01 (5 and 10 μM; 24 hours) strongly inhibits the activity of EZH2 and results in abolished H3K27me expression in K562 cells[1].
DM-01 (5 and 10 μM) also increases the transcription expression of DIRAS3 in a dose dependent manner, a tumor suppressor in downstream of EZH2[1].

Cell Viability Assay[1]

Cell Line: A549 sh-EV and A549 sh-EZH2 cells
Concentration: 1, 5, 10, 50, 100 μM
Incubation Time: 48 hours
Result: The IC50s of 72.748 and 269.7 μΜ for A549 sh-EV and A549 sh-EZH2 cells, respectively.

Western Blot Analysis[1]

Cell Line: K562 cells
Concentration: 5, 10 μM
Incubation Time: 24 hours
Result: Inhibited the activity of EZH2 and resulted in abolished H3K27me expression.
Molecular Weight

431.45

Formula

C₂₃H₂₄F₃N₃O₂

CAS No.

2355280-00-9

SMILES

O=C(C1=C(C)N(CC2=CC=C(C(F)(F)F)C=C2)C=C1C)NCC3=C(C)C=C(C)NC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
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Keywords:

DM-01DM01DM 01Histone MethyltransferaseEZH2diffuselargeB-celllymphomaDLBCLfollicularSNF5INI-1SMARCB1Inhibitorinhibitorinhibit

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DM-01
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