EZH2-IN-5
EZH2-IN-5 is a potent EZH2 inhibitor with IC50 values of 1.52 nM and 4.07 nM for wild-type and mutant Tyr641 EZH2, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1403258-69-4
- Formula: C26H37BrN4O2
- Molecular Weight:517.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
EZH2 WT 1.52 nM (IC50) |
EZH2 Y641F mutant type 4.07 nM (IC50) |
In Vitro
EZH2-IN-5 (compound 276) inhibits cell growth of WSUDLCL2 cell lines with an IC50 of 187.28 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1403258-69-4
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Molecular Weight 517.50
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Formula C26H37BrN4O2
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SMILES
CCN([C@H]1CC[C@@H](CC1)N(C)C)C2=C(C(C(NCC3=C(C=C(NC3=O)C)C)=O)=CC(Br)=C2)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EZH2-IN-5 Related Classifications
HY-141566 Related Classifications
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