1. Epigenetics
  2. Histone Methyltransferase
  3. Gambogenic acid

Gambogenic acid 

Cat. No.: HY-N5024
Handling Instructions

Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination.

For research use only. We do not sell to patients.

Gambogenic acid Chemical Structure

Gambogenic acid Chemical Structure

CAS No. : 173932-75-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 373 In-stock
Estimated Time of Arrival: December 31
1 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 269 In-stock
Estimated Time of Arrival: December 31
10 mg USD 457 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination[1].

IC50 & Target

EZH2[1]

Molecular Weight

630.77

Formula

C₃₈H₄₆O₈

CAS No.

173932-75-7

SMILES

O=C(O)/C(C)=C\C[[email protected]@]1(C2=O)OC(C)(C)[[email protected]]([[email protected]]31OC4=C5C(O)=C(C/C=C(C)/CC/C=C(C)\C)C(O)=C4C/C=C(C)\C)([H])C[[email protected]@]2([H])C=C3C5=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Keywords:

Gambogenic acidHistone MethyltransferaseInhibitorinhibitorinhibit

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Gambogenic acid
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