PROTAC EZH2 Degrader-41
PROTAC EZH2 Degrader-41 is an EZH2-targeting PROTAC and cIAP E3 ubiquitin ligase recruiter. PROTAC EZH2 Degrader-41 induces EZH2 degradation via ubiquitination and proteasomal breakdown. PROTAC EZH2 Degrader-41 exerts antiproliferative effects in lymphoma cells. PROTAC EZH2 Degrader-41 can be used for the research of lymphoma.
(Pink: EZH2 ligand (HY-147230); Blue: cIAP ligand (HY-137159); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3093642-41-9
- Formula: C63H89N11O10
- Molecular Weight:1160.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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cIAP |
EZH2 |
PROTAC EZH2 Degrader-41 (compound 57) (10.00-30.00 μM) induces EZH2 degradation at 10.00 μM and 30.00 μM in SU-DHL-6 cells, and potently inhibits the proliferation of SU-DHL-6 and HBL-1 diffuse large B-cell lymphoma cells with IC50 values of 10.22 μM and 10.17 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3093642-41-9
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Molecular Weight 1160.45
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Formula C63H89N11O10
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SMILES
CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)CN4CCN(CC4)C(CCC5=CN(N=N5)CCOCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@H](N)CC6=CC=CC=C6)=O)=O)=O)=CC(C(NCC7=C(C=C(NC7=O)C)C)=O)=C2C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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