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Art. -Nr.: HY-156615

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Igermetostat

Name: Igermetostat
Brand: MedChemExpress
SKU: HY-156615
Price: 960.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: XNW5004)

Igermetostat (XNW5004) is an orally active EZH2 inhibitor for research related to metastatic castration-resistant prostate cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2409538-60-7
Formel: C₃₂H₄₆N₄O₄
Molecular Weight:550.73

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

Igermetostat Chemical Structure

CAS. Nr.: 2409538-60-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Igermetostat (XNW5004) is an orally active EZH2 inhibitor for research related to metastatic castration-resistant prostate cancer^[1]^[2].

IC₅₀ & Target

^[1]

EZH2

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

In Vivo

Anti-cancer

Igermetostat (XNW5004) (800‑1600 mg; twice daily; oral, in combination with Enzalutamide (HY-70002) 160 mg once daily) exhibits antitumor efficacy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2409538-60-7
Molecular Weight 550.73
Formel C₃₂H₄₆N₄O₄
SMILES

O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(O[C@H]3C[C@H](N4CCCCC4)C3)=CC(N(CC)C5CCOCC5)=C2C
Synonyms

XNW5004
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chang Y, et al. A phase 1b/2 study to evaluate the safety and efficacy of igermetostat (XNW5004) in combination with enzalutamide in patients with metastatic castration‑resistant prostate cancer. Journal of Clinical Oncology. 2026;44(7_suppl):169.

[2]. Louati K, et al. The Identification by Shotgun Proteomics with High-Resolution Tandem Mass-Spectrometry of Histone Isoforms' Hypermethylation Phenotype as a Hallmark Characteristic of Human-IDH-Mutant High-Grade Gliomas: Epigenetic Applications for Genotoxicity-Based Biomarkers and Cancer Therapy Targets. Journal of proteome research. 2025 Sep 05;24(9):4503-4525.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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- In Vivo
Chemical Information
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Igermetostat

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vivo

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Igermetostat Related Classifications

HY-156615 Related Classifications

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