1. Epigenetics
  2. Histone Methyltransferase
  3. UNC2399

UNC2399 

Cat. No.: HY-136188
Handling Instructions

UNC2399, a biotinylated UNC1999, is a selective EZH2 degrader, maintaining high in vitro potency for EZH2, with an IC50 of 17 nM.

For research use only. We do not sell to patients.

UNC2399 Chemical Structure

UNC2399 Chemical Structure

CAS No. : 2412791-72-9

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Description

UNC2399, a biotinylated UNC1999, is a selective EZH2 degrader, maintaining high in vitro potency for EZH2, with an IC50 of 17 nM[1][2].

IC50 & Target[1]

EZH2

17 nM (IC50)

In Vitro

UNC2399 (1-1000 nM) displays high in vitro potency (IC50=17±2 nM) in the EZH2 radioactive biochemical assay[1].
UNC2399 (100 μM) enriches EZH2 from HEK293T cell lysates[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

927.17

Formula

C₄₈H₆₆N₁₀O₇S

CAS No.

2412791-72-9

SMILES

CC(N1C2=CC(C(C=C3)=CN=C3N4CCN(CC4)C(CCOCCCOCCNC(CCCC[[email protected]]5[[email protected]@H]6[[email protected]@H](NC(N6)=O)CS5)=O)=O)=CC(C(NCC7=C(CCC)C=C(NC7=O)C)=O)=C2C=N1)C.[11]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

UNC2399UNC 2399UNC-2399Histone MethyltransferasebiotinylatedUNC1999Inhibitorinhibitorinhibit

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