EZH2-IN-25
EZH2-IN-25 is an EZH2 inhibitor that inhibits the catalytic subunit of PRC2. EZH2-IN-25 can be used for the research of diffuse large B cell lymphoma.
For research use only. We do not sell to patients.
- CAS No.: 2636048-41-2
- Formula: C25H30ClN7O2
- Molecular Weight:496.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
EZH2 |
In Vitro
EZH2-IN-25 (example 53) selectively targets EZH2 within the PRC2 pentameric complex, exhibiting a mechanism of inhibition distinct from SAM-competitive inhibitors and EED K27me3-pocket binders[1].
EZH2-IN-25 selectively targets EZH2 in human cell lines, reducing H3K27me3 levels through a mechanism distinct from SAM-competitive and EED K27me3-pocket binders[1].
EZH2-IN-25 selectively targets EZH2 and modulates proliferation of human cancer cell lines that depend on PRC2 activity to maintain cancerous growth[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2636048-41-2
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Molecular Weight 496.00
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Formula C25H30ClN7O2
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SMILES
ClC1=NC=CC2=C1N=C(N[C@@H]3CC[C@H](CC3)CNC4=NC=C([C@H](C)C(NC5COC5)=O)C=N4)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EZH2-IN-25 Related Classifications
HY-188147 Related Classifications
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