PROTAC EZH2 Degrader-13
PROTAC EZH2 Degrader-13 is an EZH2-targeting PROTAC with an IC50 of 2.70 nM. PROTAC EZH2 Degrader-13 exerts antiproliferative effects in cancer cells. PROTAC EZH2 Degrader-13 can be used for the research of cancer.
(Pink: EZH2 ligand (HY-13470); Blue: Cereblon ligand (HY-103596); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2653338-63-5
- Formula: C51H60N8O7
- Molecular Weight:897.07
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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EZH2 2.70 nM (IC50) |
EZH1 4.50 μM (IC50) |
PROTAC EZH2 Degrader-13 (compound 4) potently inhibits EZH2 enzymatic activity (IC50 = 2.7 nM), induces CRBN-mediated proteasomal degradation of PRC2 subunits, reduces H3K27me2/3 levels, and exerts antiproliferative effects in Pfeiffer and prostate cancer cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2653338-63-5
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Molecular Weight 897.07
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Formula C51H60N8O7
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SMILES
CC[C@H](C)N1C=C(C)C2=C(C(NCC3=C(C)C=C(C)NC3=O)=O)C=C(C4=CN=C(N5CCN(CCCCCCCOC6=C7C(N(C8CCC(NC8=O)=O)C(C7=CC=C6)=O)=O)CC5)C=C4)C=C21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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