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Jarid2 - jumonji, AT rich interactive domain 2 Gene

Also Known as Jmj; jumonji

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16468

Summary

Enables several functions, including chromatin binding activity; ubiquitin binding activity; and ubiquitin modification-dependent histone binding activity. Involved in negative regulation of transcription by RNA polymerase II; regulation of histone methylation; and stem cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; hematopoietic or lymphoid organ development; and regulation of gene expression. Located in nucleus. Part of ESC/E(Z) complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human JARID2 (jumonji and AT-rich interaction domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Jarid2 Products (4)

mRNA	Protein	Name
NM_001205043.1	NP_001191972.1	protein Jumonji isoform 1
NM_001205044.1	NP_001191973.1	protein Jumonji isoform 1
NM_001360281.1	NP_001347210.1	protein Jumonji isoform 2
NM_021878.3	NP_068678.1	protein Jumonji isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12890668	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	20064375	MGI
NOT contributes to histone H3K27 methyltransferase activity	IDA IDA: Inferred from direct assay	20064375	MGI
contributes to histone H3K27 methyltransferase activity	IDA IDA: Inferred from direct assay	20064376	MGI
NOT enables histone demethylase activity	IDA IDA: Inferred from direct assay	20064376	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15542826	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	26523946	MGI
enables ubiquitin binding	IMP IMP: Inferred from mutant phenotype	27892467	MGI
enables ubiquitin-modified histone reader activity	IMP IMP: Inferred from mutant phenotype	27892467	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15870077	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15870077	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in facultative heterochromatin formation	IDA IDA: Inferred from direct assay	19010785	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	9376320	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12890668	MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15870077	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12890668	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15870077	MGI
acts upstream of or within protein localization to pericentric heterochromatin	IMP IMP: Inferred from mutant phenotype	27892467	MGI
acts upstream of or within random inactivation of X chromosome	IMP IMP: Inferred from mutant phenotype	27892467	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11301191	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	9376320	MGI
involved in stem cell differentiation	IMP IMP: Inferred from mutant phenotype	20064375	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	9376320	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	20064375	MGI
part of histone methyltransferase complex	IDA IDA: Inferred from direct assay	19010785	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12890668	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein Jumonji	jumonji/ARID domain-containing protein 2

Jarid2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Jarid2	Q62315	Suz12	Mus musculus	Q80U70	Anti Bait CoIP	20075857
Intra	Jarid2	Q62315	Suz12	Mus musculus	Q80U70	Anti Tag CoIP	20064376
Intra	Jarid2	Q62315	Suz12	Mus musculus	Q80U70	Anti Bait CoIP	21811233
Intra	Jarid2	Q62315	Suz12	Mus musculus	Q80U70	Anti Bait CoIP	20064375
Intra	Jarid2	Q62315	Suz12	Mus musculus	Q80U70	Anti Bait CoIP	20064376
Intra	Jarid2	Q62315	Suz12	Mus musculus	Q80U70	Pull Down	20064375
Intra	Jarid2	Q62315	Ezh1	Mus musculus	P70351	Anti Tag CoIP	20064376
Intra	Jarid2	Q62315	Gata4	Mus musculus	Q08369	Pull Down	15542826
Intra	Jarid2	Q62315	Gata4	Mus musculus	Q08369	Anti Tag CoIP	15542826
Intra	Jarid2	Q62315	Nkx2-5	Mus musculus	P42582	Anti Tag CoIP	15542826
Intra	Jarid2	Q62315	Nkx2-5	Mus musculus	P42582	Pull Down	15542826
Intra	Jarid2	Q62315	Znf496	Mus musculus	Q5SXI5	Y2H	17521633
Intra	Jarid2	Q62315	Eed	Mus musculus	Q921E6	Anti Bait CoIP	20064376
Intra	Jarid2	Q62315	Eed	Mus musculus	Q921E6	Anti Tag CoIP	20064376
Intra	Jarid2	Q62315	Ezh2	Mus musculus	Q61188	Anti Bait CoIP	21811233
Intra	Jarid2	Q62315	Ezh2	Mus musculus	Q61188	Anti Bait CoIP	20064375
Intra	Jarid2	Q62315	Ezh2	Mus musculus	Q61188	Anti Tag CoIP	20064376
Intra	Jarid2	Q62315	Ezh2	Mus musculus	Q61188	Anti Bait CoIP	20064376
Intra	Jarid2	Q62315	Ezh2	Mus musculus	Q61188	GMS	20064376

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07030	JARID2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19784	Jarid2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26281	Jarid2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Jarid2	NCBI	NCBI:3720