Ezh1 - enhancer of zeste 1 polycomb repressive complex 2 subunit Gene

Also Known as ENX-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14055

About Ezh1

Chromosome 11: 101,081,941-101,117,289 reverse strand.GRCm39:CM001004.3

This gene has 9 transcripts (splice variants), 234 orthologues, 20 paralogues and is associated with 13 phenotypes. Ubiquitous expression in lung adult (RPKM 16.7), kidney adult (RPKM 16.3) and 28 other tissues.

Summary

This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (EZH2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 and results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]

Ezh1 Products (13)

mRNA Protein Name
NM_001403815.1 NP_001390744.1 histone-lysine N-methyltransferase EZH1 isoform 9
NM_001403812.1 NP_001390741.1 histone-lysine N-methyltransferase EZH1 isoform 6
NM_001403811.1 NP_001390740.1 histone-lysine N-methyltransferase EZH1 isoform 5
NM_001403809.1 NP_001390738.1 histone-lysine N-methyltransferase EZH1 isoform 3
NM_001403822.1 NP_001390751.1 histone-lysine N-methyltransferase EZH1 isoform 4
NM_001403807.1 NP_001390736.1 histone-lysine N-methyltransferase EZH1 isoform 2
NM_001403821.1 NP_001390750.1 histone-lysine N-methyltransferase EZH1 isoform 1
NM_001403814.1 NP_001390743.1 histone-lysine N-methyltransferase EZH1 isoform 8
NM_001403816.1 NP_001390745.1 histone-lysine N-methyltransferase EZH1 isoform 10
NM_001403810.1 NP_001390739.1 histone-lysine N-methyltransferase EZH1 isoform 4
NM_001403818.1 NP_001390747.1 histone-lysine N-methyltransferase EZH1 isoform 11
NM_001403813.1 NP_001390742.1 histone-lysine N-methyltransferase EZH1 isoform 7
NM_007970.4 NP_031996.1 histone-lysine N-methyltransferase EZH1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables DNA binding IDA
IDA: Inferred from direct assay
19026781 MGI
enables histone H3K27 methyltransferase activity IDA
IDA: Inferred from direct assay
19303854 MGI
contributes to histone binding IDA
IDA: Inferred from direct assay
19026781 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9584197 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
19026781 MGI
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
19026781 MGI
involved in facultative heterochromatin formation IDA
IDA: Inferred from direct assay
20064376 MGI
acts upstream of or within hepatocyte homeostasis IGI
IGI: Inferred from genetic interaction
25477280 MGI
involved in heterochromatin formation IDA
IDA: Inferred from direct assay
19026781 MGI
acts upstream of or within liver regeneration IGI
IGI: Inferred from genetic interaction
25477280 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19026781 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19303854 MGI
acts upstream of or within response to tetrachloromethane IGI
IGI: Inferred from genetic interaction
25477280 MGI
involved in subtelomeric heterochromatin formation IGI
IGI: Inferred from genetic interaction
9214638 MGI
Cellular Component GO Annotation Evidence References Source
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
19026781 MGI
located in chromosome, telomeric region IGI
IGI: Inferred from genetic interaction
9214638 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
19026781 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9584197 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ezh1 Protein Structure

EZH2_WD-Binding

EZH2_WD-Binding: pfam11616 (41 - 70)

PRC2_HTH_1

PRC2_HTH_1: pfam18118 (161 - 264)

SANT

SANT: cd00167 (435 - 476)

SET

SET: cl34524 (465 - 729)

SET_EZH1

SET_EZH1: cd19217 (610 - 745)

  • 0
  • 200
  • 400
  • 600
  • 750 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EZH1

  • enhancer of zeste homolog 1

Ezh1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ezh1 P70351 Mtf2 Mus musculus Q02395
Anti Tag CoIP
20064376
Intra
Ezh1 P70351 Jarid2 Mus musculus Q62315
Anti Tag CoIP
20064376
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109108 Valemetostat Inhibitor 99.84% Unkown
HY-109108A Valemetostat tosylate Inhibitor 99.84% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145602 Tulmimetostat Inhibitor 99.79% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15646 UNC1999 Inhibitor 99.87% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-144881 (S)-HH2853 Inhibitor / Unkown
HY-181327 PROTAC EZH2 Degrader-26 Degrader / Unkown
HY-180553 NSD2-IN-6 Inhibitor / Unkown
HY-181308 PROTAC EZH2 Degrader-13 Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ezh1 NCBI NCBI:2145