JARID2 - jumonji and AT-rich interaction domain containing 2 Gene

Also Known as JMJ; DIDDF

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 3720

About JARID2

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:15,246,069-15,522,042 (from NCBI)

This gene has 3 transcripts (splice variants), 221 orthologues, 10 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 19.2), testis (RPKM 12.2) and 23 other tissues.

Summary

This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]

JARID2 Products (2)

mRNA Protein Name
NM_001267040.1 NP_001253969.1 protein Jumonji isoform 2
NM_004973.4 NP_004964.2 protein Jumonji isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
20075857 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in nucleus IDA
IDA: Inferred from direct assay
20075857 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JARID2 Protein Structure

JmjN

JmjN: jmjN domain (558 - 591)

ARID

ARID: ARID/BRIGHT DNA binding domain (619 - 709)

JmjC

JmjC: JmjC domain, hydroxylase (916 - 1031)

zf-C5HC2

zf-C5HC2: C5HC2 zinc finger (1139 - 1193)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1246 a.a.
Protein Preferred Names Protein Names

protein Jumonji

  • jumonji homolog

JARID2 抗体

製品番号 製品名 アプリケーション 反応性
HY-P82265 Protein Jumonji Antibody (YA2010) WB, ICC/IF Human
HY-P84707 Protein Jumonji Antibody (YA4404) ICC/IF, FC, ELISA Human
HY-P84707A Protein Jumonji Antibody (YA4404)(PBS only) ICC/IF, FC, ELISA Human

関連疾患

Diseases Alias
Non-Specific Syndromic Intellectual Disability

  • Complex Neurodevelopmental Disorder
Autosomal Dominant Non-Syndromic Intellectual Disability
Tetralogy Of Fallot

  • TOF

  • Fallot Tetralogy

  • Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

  • Tetrad Of Fallot

  • Fallot Tetrad

  • Fallot Disease

  • Fallot Complex

  • Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

  • Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

  • Interventricular Septal Defect, In Tetralogy Of Fallot

  • Ventricular Septal Defect With Obstructed Right Ventricular Outflow

  • Tof - [Tetralogy Of Fallot]

  • Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

  • Pulmonary Atresia, Ventricular Septal Defect And Mapcas

  • Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Weaver Syndrome

  • Wss

  • Weaver-Smith Syndrome

  • WVS

  • Weaver-Like Syndrome

  • Weaver-Williams Syndrome

  • Camptodactyly-Overgrowth-Unusual Facies Syndrome

  • Camptodactyly - Overgrowth - Unusual Facies

  • Ezh2 Related Overgrowth

  • Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly

  • Weaver Smith Syndrome

  • Weaver Like Syndrome

  • Weaver Williams Syndrome

  • Camptodactyly-Overgrowth-Unusual Facies

  • Weaver Syndrome 1

  • Weaver Syndrome 2

  • Wvs1

  • Wvs2
Rhabdomyosarcoma
Kabuki Syndrome 1

  • Kabuki Syndrome

  • Niikawa-Kuroki Syndrome

  • Kabuki Make-Up Syndrome

  • Kms

  • KABUK1

  • Kabuki Make Up Syndrome

  • Nks

  • Kabuki Makeup Syndrome

  • Kabuki Syndrome, Type 1
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Double Outlet Right Ventricle

  • Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect

  • Taussig-Bing Syndrome

  • Dextrotransposition Of Aorta

  • Taussig-Bing Syndrome Or Defect

  • Dorv

  • Dorv With Subpulmonary Vsd

  • Dorv-Tga

  • Double Outlet Right Ventricle With Transposition Of The Great Arteries

  • Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type

  • Taussig-Bing Heart

  • Taussig-Bing Malformation

  • Taussig-Bing Complex

  • Taussig-Bing Defect

  • Taussig-Bing

  • Double Outlet Right Ventricle With Remote Ventricular Septal Defect

  • Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect

  • Double Outlet Right Ventricle With Non-Committed Interventricular Communication

  • Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis

  • Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS07030 JARID2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19784 Jarid2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26281 Jarid2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus JARID2 VGNC VGNC:30371
Canis familiaris JARID2 VGNC VGNC:42181
Rattus norvegicus JARID2 RGD RGD:1591663
Macaca mulatta JARID2 VGNC VGNC:73956
Felis catus JARID2 VGNC VGNC:67879
Mus musculus JARID2 MGD MGI:104813
Others JARID2 NCBI