Dgkz - diacylglycerol kinase zeta Gene

Also Known as mDGK[z]; E130307B02Rik; F730209L11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 104418

Summary

Enables diacylglycerol kinase activity and enzyme inhibitor activity. Involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and maintenance of postsynaptic density structure. Acts upstream of or within negative regulation of Ras protein signal transduction. Located in Schaffer collateral - CA1 synapse. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human DGKZ (diacylglycerol kinase zeta). [provided by Alliance of Genome Resources, Apr 2022]

Dgkz Products (2)

mRNA	Protein	Name
NM_001166597.1	NP_001160069.1	diacylglycerol kinase zeta isoform 1
NM_138306.2	NP_612179.2	diacylglycerol kinase zeta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP-dependent diacylglycerol kinase activity	IMP IMP: Inferred from mutant phenotype	12883552	MGI
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	15894621	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16286473	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	15894621	MGI
involved in diacylglycerol metabolic process	IMP IMP: Inferred from mutant phenotype	12883552	MGI
involved in lipid phosphorylation	IMP IMP: Inferred from mutant phenotype	12883552	MGI
involved in maintenance of postsynaptic density structure	IDA IDA: Inferred from direct assay	19229292	MGI
involved in maintenance of postsynaptic density structure	IEP IEP: Inferred from expression pattern	19229292	MGI
involved in maintenance of postsynaptic density structure	IMP IMP: Inferred from mutant phenotype	19229292	MGI
acts upstream of or within negative regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	15894621	MGI
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12883552	MGI
involved in phosphatidic acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	12883552	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	19229292	MGI
is active in Schaffer collateral - CA1 synapse	IEP IEP: Inferred from expression pattern	19229292	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	19229292	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19229292	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	19229292	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19229292	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
diacylglycerol kinase zeta	DAG kinase zeta DGK-zeta diglyceride kinase zeta

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135898	DGK-IN-1	Inhibitor	98.67%	Unkown
HY-RS03724	DGKZ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dgkz	NCBI	NCBI:8525