DGKZ - diacylglycerol kinase zeta Gene

Also Known as DAGK5; DAGK6; DGK-ZETA; hDGKzeta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8525

About DGKZ

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,332,926-46,380,554 (from NCBI)

This gene has 24 transcripts (splice variants), 273 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 24.7), bone marrow (RPKM 15.6) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

DGKZ Products (7)

mRNA Protein Name
NM_001105540.2 NP_001099010.1 diacylglycerol kinase zeta isoform 4
NM_001199266.2 NP_001186195.1 diacylglycerol kinase zeta isoform 5
NM_001199267.2 NP_001186196.1 diacylglycerol kinase zeta isoform 6
NM_001199268.2 NP_001186197.1 diacylglycerol kinase zeta isoform 7
NM_003646.4 NP_003637.2 diacylglycerol kinase zeta isoform 2
NM_201532.3 NP_963290.1 diacylglycerol kinase zeta isoform 1
NM_201533.3 NP_963291.2 diacylglycerol kinase zeta isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: Inferred from direct assay
15544348 GOA
enables kinase activity IDA
IDA: Inferred from direct assay
18004883 GOA
enables lipid kinase activity IDA
IDA: Inferred from direct assay
16286473 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15157668 GOA
Biological Process GO Annotation Evidence References Source
involved in diacylglycerol metabolic process IDA
IDA: Inferred from direct assay
15544348 GOA
involved in glycerolipid metabolic process IDA
IDA: Inferred from direct assay
22627129 GOA
involved in lipid phosphorylation IDA
IDA: Inferred from direct assay
15544348 GOA
involved in mitotic G1 DNA damage checkpoint signaling IGI
IGI: Inferred from genetic interaction
16286473 GOA
involved in phosphatidic acid biosynthetic process IDA
IDA: Inferred from direct assay
15544348 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
22627129 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
15157668 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15157668 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKZ Protein Structure

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (361 - 419)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (484 - 608)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (635 - 792)

Ank_5

Ank_5: Ankyrin repeats (many copies) (1031 - 1087)

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  • 1000
  • 1117 a.a.
Protein Preferred Names Protein Names

diacylglycerol kinase zeta

  • DAG kinase zeta

DGKZ Antibodies

Cat. No. Product Name Application Reactivity
HY-P81477 DGKZ Antibody (YA1222) IHC-P Human, Rat
HY-P81477A DGKZ Antibody (YA1222)(PBS only) IHC-P Human, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135898 DGK-IN-1 Inhibitor 98.67% Unkown
HY-RS03724 DGKZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DGKZ VGNC VGNC:39924
Macaca mulatta DGKZ VGNC VGNC:71789
Bos taurus DGKZ VGNC VGNC:54417
Rattus norvegicus DGKZ RGD RGD:70929
Mus musculus DGKZ MGD MGI:1278339
Felis catus DGKZ VGNC VGNC:61464
Others DGKZ NCBI