DGKZ Antibody (YA1222)(PBS only)
(Synonyms: DAGK5; DAGK6; DGK-ZETA; hDGKzeta)DGKZ Antibody (YA1222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DGKZ.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:2000-1:5000 |
Product Details
DGKZ Antibody (YA1222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DGKZ.
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Host Rabbit
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 124/114 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 104 kDa
Recombinant protein of human DGKZ
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DGKZ is a Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group. The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol. By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization. Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane; Regulates RASGRP1 activity; Does not regulate RASGRP1 activity[1][2][3][4][5][6][7][8].
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Subcellular Localization
Nucleus; Cytoplasm, cytosol; Cell membrane; Cell projection, lamellipodium
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Expression
Tissue_specificity:Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas; Predominantly expressed in muscle -
Isoforms & Post-Translational Modification
Q13574 has 7 isomers: Q13574-2: 103981 Da (predicted); Q13574-1: 124128 Da (predicted); Q13574-3: 106030 Da (predicted); Q13574-4: 104109 Da (predicted); Q13574-5: 104581 Da (predicted); Q13574-6: 101230 Da (predicted); Q13574-7: 104296 Da (predicted).
Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta -
Subunit
Interacts (via PDZ-binding motif) with the PDZ domain of the syntrophin SNTG1 and that of SNX27 (PubMed:11352924, PubMed:17351151).
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SwissProt ID
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Synonyms
DAGK5; DAGK6; DGK-ZETA; hDGKzeta
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Research Field
Signal Transduction
Documentation
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