SLC25A17 - solute carrier family 25 member 17 Gene

Also Known as PMP34

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10478

About SLC25A17

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:40,769,630-40,819,346 (from NCBI)

This gene has 17 transcripts (splice variants), 200 orthologues and 49 paralogues. Ubiquitous expression in ovary (RPKM 10.5), thyroid (RPKM 8.4) and 25 other tissues.

Summary

This gene encodes a peroxisomal membrane protein that belongs to the family of mitochondrial solute carriers. It is expressed in the liver, and is likely involved in transport. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

SLC25A17 Products (3)

mRNA	Protein	Name
NM_001282726.2	NP_001269655.1	peroxisomal membrane protein PMP34 isoform 2
NM_001282727.2	NP_001269656.1	peroxisomal membrane protein PMP34 isoform 3
NM_006358.4	NP_006349.1	peroxisomal membrane protein PMP34 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP transmembrane transporter activity	IDA IDA: Inferred from direct assay	22185573	GOA
enables AMP transmembrane transporter activity	IDA IDA: Inferred from direct assay	22185573	GOA
enables ATP transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	12445829	GOA
enables FAD transmembrane transporter activity	IDA IDA: Inferred from direct assay	22185573	GOA
enables FMN transmembrane transporter activity	IDA IDA: Inferred from direct assay	22185573	GOA
enables NAD transmembrane transporter activity	IDA IDA: Inferred from direct assay	22185573	GOA
enables coenzyme A transmembrane transporter activity	IDA IDA: Inferred from direct assay	22185573	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10704444	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	11402059	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ATP transport	IGI IGI: Inferred from genetic interaction	12445829	GOA
involved in fatty acid beta-oxidation	IGI IGI: Inferred from genetic interaction	12445829	GOA
involved in fatty acid transport	IGI IGI: Inferred from genetic interaction	12445829	GOA
involved in nucleotide transmembrane transport	IDA IDA: Inferred from direct assay	22185573	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	11121399	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	9874197	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A17 Protein Structure

Mito_carr

0
100
200
307 a.a.

Protein Preferred Names	Protein Names
peroxisomal membrane protein PMP34	solute carrier family 25 (mitochondrial carrier

SLC25A17 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC25A17	O43808	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SLC25A17	O43808	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	SLC25A17	O43808	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SLC25A17	O43808	PEX19	Homo sapiens	P40855	Anti Tag CoIP	14709540
Intra	SLC25A17	O43808	PEX19	Homo sapiens	P40855	Far-WB	10704444

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Peroxisomal Disease	Peroxisomal Disorder Peroxisomal Disorders Peroxisomal Defects
Adrenoleukodystrophy	X-Linked Adrenoleukodystrophy ALD Siemerling-Creutzfeldt Disease X-Ald X-Linked Cerebral Adrenoleukodystrophy Bronze Schilder Disease Melanodermic Leukodystrophy Addison Disease And Cerebral Sclerosis Adrenomyeloneuropathy, Adult Diffuse Sclerosis X-Cald Adrenomyeloneuropathy Encephalitis Periaxialis Concentrica Encephalitis Periaxialis, Schilder'S Sudanophilic Cerebral Sclerosis Ald Childhood Cerebral Form Adrenoleukodystrophy X-Linked Cerebral Form Adrenoleukodystrophy Childhood Cerebral Form Childhood Cerebral Ald Schilder Disease X-Linked Ald Adrenoleukodystrophy, X-Linked Amn Diffuse Cerebral Sclerosis Of Schilder Systemic Scleroderma Balo'S Concentric Sclerosis Ald - [Adrenoleukodystrophy] Addison-Schilder
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Retinal Dystrophy With Leukodystrophy	RDLKD Acbd5 Deficiency Dystrophy, Retinal, With Leukodystrophy
Rhizomelic Chondrodysplasia Punctata	Chondrodysplasia Punctata, Rhizomelic Rcdp Chondrodysplasia Punctata, Rhizomelic Form Rcp Chondrodysplasia Punctata Rhizomelic
Bile Acid Synthesis Defect, Congenital, 5	Congenital Bile Acid Synthesis Defect 5 CBAS5 Bile Acid Synthesis Defect, Congenital, Type 5
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Klippel-Feil Syndrome 4
Cerebral Degeneration	Brain Degeneration Degenerative Brain Disorder
Demyelinating Disease	Demyelinating Diseases Demyelinating Disorder
Chromosome Xp21 Deletion Syndrome	Complex Glycerol Kinase Deficiency Xp21 Microdeletion Syndrome Monosomy Xp21 Xp21 Deletion Syndrome Complex Gkd Del Xp21 Contiguous Gene Deletion Syndrome Glycerol Kinase Deficiency - Contiguous Gene Syndrome
Acatalasemia	Acatalasia Catalase Deficiency Deficiency Of Catalase ACATLAS Takahara'S Disease Takahara Disease
Peroxisome Biogenesis Disorder 1b	Peroxisome Biogenesis Disorder Infantile Refsum Disease Infantile Phytanic Acid Storage Disease PBD1B Refsum Disease, Infantile Adrenoleukodystrophy, Autosomal Neonatal Ird Mild Pbd-Zsd Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Pbd-Zsd Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Autosomal Neonatal Adrenoleukodystrophy Refsum Disease Infantile Peroxisome Biogenesis Disorders Peroxisome Biogenesis Disorder, Type 1b
Chondrodysplasia Punctata Syndrome	Chondrodysplasia Punctata Chondrodysplasia Punctata Congenita Toriello Higgins Miller Syndrome Chondrodysplasia Punctata, Toriello Type Toriello-Higgins-Miller Syndrome Cdp Chondrodysplasia Punctata, X-Linked Dominant Type Chondrodysplasia Punctata Group Dysplasia Punctata Epiphysis Dysplasia Punctata Dysplasia Epiphysealis Punctata Chondrodystrophy Of Punctata
Refsum Disease, Classic	Refsum Disease Heredopathia Atactica Polyneuritiformis Phytanic Acid Oxidase Deficiency Hmsn Iv Refsum Disease, Adult, 1 Refsum'S Disease Phytanic Acid Storage Disease Hereditary Motor And Sensory Neuropathy Iv Hmsn4 Hmsn Type Iv Hmsn 4 Adult Refsum Disease Classic Refsum Disease Hereditary Motor And Sensory Neuropathy Type Iv Refsum Syndrome Hsmn Iv Disorder Of Cornification 11 Doc 11 Hereditary Sensory And Motor Neuropathy Type 4 Hypertrophic Neuropathy Of Refsum Ard Crd Hereditary Motor And Sensory Neuropathy Type 4 Phytanic-Coa Hydroxylase Deficiency RD
Leukodystrophy	Leukodystrophies
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13097	SLC25A17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC25A17	VGNC	VGNC:34746
Felis catus	SLC25A17	VGNC	VGNC:65259
Canis familiaris	SLC25A17	VGNC	VGNC:46296
Mus musculus	SLC25A17	MGD	MGI:1342248
Macaca mulatta	SLC25A17	VGNC	VGNC:98447
Rattus norvegicus	SLC25A17	RGD	RGD:1311498
Others	SLC25A17	NCBI