COLEC10 - collectin subfamily member 10 Gene

Also Known as 3MC3; CLL1; CL-10; CL-34

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10584

About COLEC10

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:118,952,263-119,108,455 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in liver (RPKM 17.0), placenta (RPKM 3.8) and 2 other tissues.

Summary

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The Other members of this family are secreted proteins and bind to carbohydrate antigens on Microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than Other C-lectins. [provided by RefSeq, Jul 2008]

COLEC10 Products (2)

mRNA Protein Name
NM_001324095.2 NP_001311024.1 collectin-10 isoform 2
NM_006438.5 NP_006429.2 collectin-10 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemoattractant activity IDA
IDA: Inferred from direct assay
28301481 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24174618 GOA
Biological Process GO Annotation Evidence References Source
involved in complement activation, lectin pathway IDA
IDA: Inferred from direct assay
24174618 GOA
involved in cranial skeletal system development IMP
IMP: Inferred from mutant phenotype
28301481 GOA
involved in positive regulation of opsonization IDA
IDA: Inferred from direct assay
24174618 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
24174618 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10224141 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
28301481 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COLEC10 Protein Structure

Collagen

Collagen: Collagen triple helix repeat (20 copies) (46 - 95)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (62 - 117)

Lectin_C

Lectin_C: Lectin C-type domain (166 - 272)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

collectin-10

  • collectin liver 1

COLEC10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
COLEC10 Q9Y6Z7 COLEC11 Homo sapiens Q9BWP8
ELISA
24174618
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
3mc Syndrome 3

  • 3MC3

  • Malpuech Facial Clefting Syndrome

  • Facial Clefting Syndrome, Gypsy Type

  • Malpuech Facial Clefting Syndrome, Formerly

  • Facial Clefting Syndrome Gypsy Type

  • Malpuech Syndrome

  • 3mc Syndrome, Type 3
3mc Syndrome

  • Craniofacial-Ulnar-Renal Syndrome

  • Malpuech Facial Clefting Syndrome

  • Oculopalatoskeletal Syndrome

  • Carnevale Syndrome

  • Michels Syndrome

  • Malpuech-Michels-Mingarelli-Carnevale Syndrome

  • Carnevale-Krajewska-Fischetto Syndrome

  • Craniosynostosis With Lid Anomalies

  • Malpuech Syndrome

  • Mingarelli Syndrome

  • Oculo-Skeletal-Abdominal Syndrome

  • Osa Syndrome

  • Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia

  • Ptosis-Strabismus-Rectus Abdominis Diastasis
3mc Syndrome 2

  • 3MC2

  • Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia

  • Oculo-Skeletal-Abdominal Syndrome

  • Osa Syndrome

  • Carnevale Syndrome

  • Carnevale Syndrome, Formerly

  • Carnevale Krajewska Fischetto Syndrome

  • 3mc Syndrome, Type 2
3mc Syndrome 1

  • Oculopalatoskeletal Syndrome

  • 3MC1

  • Craniosynostosis With Lid Anomalies

  • Michels Syndrome, Formerly

  • Michels Syndrome

  • 3mc Syndrome, Type 1
Blepharophimosis
Properdin Deficiency, X-Linked

  • Properdin Deficiency

  • PFD

  • CFPD

  • Properdin P Factor Deficiency

  • Complement Factor Properdin Deficiency

  • X-Linked Properdin Deficiency

  • Properdin Deficiency, Type I

  • Properdin Deficiency, Type 1

  • Properdin Deficiency Disease
Van Maldergem Syndrome 1

  • Cerebrofacioarticular Syndrome

  • VMLDS1

  • Van Maldergem Syndrome

  • Cerebro-Facio-Articular Syndrome

  • Van Maldergem Wetzburger Verloes Syndrome
Learning Disability

  • Learning Disabilities

  • Learning Disorders

  • Academic Skill Disorder

  • Learning Disorder
Craniosynostosis

  • Premature Closure Of Cranial Sutures

  • Craniostenosis

  • Craniosynostosis Syndrome

  • Cso

  • Craniosynostoses

  • Congenital Ossification Of Cranial Sutures

  • Congenital Ossification Of Sutures Of Skull

  • Craniostosis

  • Imperfect Fusion Of Skull

  • Congenital Imperfect Closure Skull

  • Imperfect Closure Skull

  • Premature Closure Cranium Sutures

  • Deficiency Of Craniofacial Axis
Radioulnar Synostosis

  • Radio-Ulnar Synostosis Type 1
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03003 COLEC10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19089 Colec10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25579 Colec10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus COLEC10 RGD RGD:1307149
Felis catus COLEC10 VGNC VGNC:81642
Canis familiaris COLEC10 VGNC VGNC:39488
Mus musculus COLEC10 MGD MGI:3606482
Bos taurus COLEC10 VGNC VGNC:53852
Macaca mulatta COLEC10 VGNC VGNC:71309
Others COLEC10 NCBI