SLC26A1 - solute carrier family 26 member 1 Gene

Also Known as CAON; EDM4; SAT1; SAT-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10861

About SLC26A1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:978,991-993,404 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues, 9 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 6.4), liver (RPKM 1.9) and 19 other tissues.

Summary

This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008]

SLC26A1 Products (3)

mRNA Protein Name
NM_022042.4 NP_071325.2 sulfate anion transporter 1 isoform a
NM_134425.4 NP_602297.1 sulfate anion transporter 1 isoform b
NM_213613.4 NP_998778.1 sulfate anion transporter 1 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables solute:inorganic anion antiporter activity IDA
IDA: Inferred from direct assay
12713736 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC26A1 Protein Structure

(54 - 137)

Sulfate_transp

Sulfate_transp: Sulfate permease family (195 - 473)

STAS

STAS: STAS domain (535 - 683)

  • 0
  • 200
  • 400
  • 600
  • 701 a.a.
Protein Preferred Names Protein Names

sulfate anion transporter 1

  • solute carrier family 26 (anion exchanger), member 1

Related Diseases

Diseases Alias
Nephrolithiasis, Calcium Oxalate

  • Kidney Stones

  • Calculus Of Kidney

  • Kidney Calculi

  • Nephrolithiasis

  • Renal Calculi

  • Calcium Oxalate Urolithiasis

  • CAON

  • Urolithiasis, Calcium Oxalate

  • Calcium Oxalate Nephrolithiasis

  • Kidney Stone

  • Nephrolith

  • Renal Calculus

  • Urinary Stones

  • Renal Stone

  • Calculus, Kidney

  • Calculus, Renal

  • Renal Lithiasis

  • Renal Stones

  • Urolithiasis

  • Renal Calculus Or Stone

  • Stone In Kidney

  • Nephritic Calculus

  • Multiple Kidney Calculi

  • Multiple Kidney Calculus

  • Nephrolithiasis Nos

  • Pelvic Nephrolithiasis

  • Pelviolithiasis

  • Pelvis Nephrolithiasis
Hurler Syndrome

  • Mucopolysaccharidosis Ih

  • Mucopolysaccharidosis Type Ih

  • Mps1-H

  • MPS1H

  • Hurler Disease

  • Mpsih

  • Mucopolysaccharidosis Type 1h

  • Alpha-L-Iduronidase Deficiency

  • Dysostosis Multiplex

  • Dysostosis Multiplex Syndrome

  • Gargoylism

  • Hurler Disease Mps Type 1h

  • Hurler-Pfaundler Syndrome

  • L-Iduronidase Deficiency, Hurler Type

  • Mucopolysaccharidosis Type I Severe Form

  • Mucopolysaccharidosis 1h

  • Hurler'S Syndrome

  • Mps Ih

  • Mps-Ih

  • Pfaundler-Hurler Syndrome

  • Mucopolysaccharidosis I
Hurler-Scheie Syndrome

  • Mucopolysaccharidosis Type Ih/S

  • Mucopolysaccharidosis Ih/S

  • MPS1H/S

  • Mpsih/S

  • Mucopolysaccharidosis Type 1h/S

  • Mps1-Hs

  • Alpha-L-Iduronidase Deficiency

  • Mucopolysaccharidosis I

  • Mucopolysaccharidosis 1h/S

  • Mps-Ih/S
Scheie Syndrome

  • Mucopolysaccharidosis Type Is

  • Alpha-L-Iduronidase Deficiency

  • Mucopolysaccharidosis Type I

  • Mucopolysaccharidosis I

  • Hurler-Scheie Syndrome

  • Mucopolysaccharidosis Type 1

  • Mucopolysaccharidosis Is

  • Mucopolysaccharidosis Type 1s

  • Mucopolysaccharidosis Type V

  • Hurler Syndrome

  • Idua Deficiency

  • Mps I

  • MPS1S

  • Mps1-S

  • Mucopolysaccharidosis Type V, Formerly

  • Mps V, Formerly

  • Mps5, Formerly

  • Lipochondrodystrophy

  • Mpsis

  • Mucopolysaccharidosis, Type I

  • Iduronidase Deficiency Disease

  • Mps I - Hurler Syndrome

  • Mucopolysaccharidosis, Mps-I

  • Mucopolysaccharidosis, Type 1

  • Attenuated Mps I

  • Mps 1

  • Scheie Syndrome Formerly Known As Mucopolysaccharidosis Type V)

  • Severe Mps I

  • Mps I H

  • Mps I H-S

  • Mps I S

  • Mps1

  • Mpsi

  • Mucopolysaccharidosis 1s

  • Mps Is

  • Mps-Is

  • Mps V

  • Mucopolysaccharidosis V

  • Pfaundler-Hurler Syndrome

  • L-Iduronidase Deficiency

  • Dysostosis Multiplex

  • Dysostosis Multiplex Syndrome

  • Gargoylism

  • Mps1 - [Mucopolysaccharidosis Type 1]
Nephrolithiasis

  • Kidney Stones

  • Stone - Kidney/Ureter

  • Kidney Calculi
Urolithiasis
Diastrophic Dysplasia

  • Diastrophic Dwarfism

  • DTD

  • Dd

  • Diastrophic Dysplasia, Broad Bone-Platyspondylic Variant

  • Dysplasia, Diastrophic

  • Diastrophic Dysplasia Variant
Thiamine Metabolism Dysfunction Syndrome 2

  • Biotin-Responsive Basal Ganglia Disease

  • Basal Ganglia Disease, Biotin-Responsive

  • THMD2

  • Bbgd

  • Btbgd

  • Encephalopathy, Thiamine-Responsive

  • Thiamine Metabolism Dysfunction Syndrome 2, Biotin- Or Thiamine-Responsive Type

  • Thiamine-Responsive Encephalopathy
Brown-Vialetto-Van Laere Syndrome 2

  • BVVLS2

  • Rfvt3-Related Riboflavin Transporter Deficiency

  • Rtd3

  • Riboflavin Transporter Deficiency 3

  • Brown-Vialetto-Van Laere Syndrome, Type 2
Atelosteogenesis

  • Atelosteogenesis, Type 1
Pendred Syndrome

  • Goiter-Deafness Syndrome

  • Deafness With Goiter

  • PDS

  • Thyroid Dyshormonogenesis 2b

  • Tdh2b

  • Autosomal Recessive Sensorineural Hearing Impairment And Goiter

  • Pendred'S Syndrome

  • Thyroid Hormonogenesis, Genetic Defect In, 2b

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b

  • Congenital Hypothyroidism Due To Dyshormonogenesis 2b

  • Genetic Defect In Thyroid Hormonogenesis 2b

  • Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter

  • Goiter-Hearing Loss Syndrome

  • Goitre-Deafness Syndrome

  • Goitre Deafness
Renal Tubular Acidosis

  • Acidosis Renal Tubular

  • Acidosis, Renal Tubular

  • Lightwood-Albright Syndrome

  • Lightwood Syndrome

  • Idiopathic Infantile Hypercalcemia - Mild Form

  • Kidney Tubular Acidosis

  • Renal Tubule Acidosis

  • Kidney Acidosis

  • Renal Acidosis

  • Renal Hyperchloremic Acidosis

  • Rta - [Renal Tubular Acidosis]
Cystinuria

  • CSNU

  • Cystinuria Type B

  • Cystinuria Type A

  • Cystinuria, Type I, Formerly

  • Csnu1, Formerly

  • Cystinuria, Type Ii, Formerly

  • Cystinuria, Type Iii, Formerly

  • Csnu3, Formerly

  • Cystinuria, Type Non-I, Formerly

  • Cystinuria-Lysinuria

  • Cystinuria-Lysinuria Syndrome

  • Csnu1

  • Csnu3

  • Cystinuria 1

  • Cystinuria Type A/B

  • Cystinuria Type I

  • Cystinuria Type Ii

  • Cystinuria Type Iii

  • Cystinuria Type Non-I

  • Cystinuria, Type A/B

  • Cystinuria Type 1

  • Cystinuria - Lysinuria

  • Csnu - [Cystinuria]

  • Cystine Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13134 SLC26A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC26A1 RGD RGD:620136
Mus musculus SLC26A1 MGD MGI:2385894
Macaca mulatta SLC26A1 VGNC VGNC:77437
Canis familiaris SLC26A1 VGNC VGNC:46320
Bos taurus SLC26A1 VGNC VGNC:34775