2. Gene
  3. MID2 - midline 2 Gene

MID2 - midline 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FXY2; RNF60; TRIM1; MRX101; XLID101

Gene ID: 11043 | Gene type: protein coding

About MID2

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:107,825,735-107,931,637 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues, 80 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 3.8), fat (RPKM 3.4) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

MID2 Products(4)

mRNA Protein Name
NM_001382751.1 NP_001369680.1 probable E3 ubiquitin-protein ligase MID2 isoform 3
NM_001382752.1 NP_001369681.1 probable E3 ubiquitin-protein ligase MID2 isoform 4
NM_012216.4 NP_036348.2 probable E3 ubiquitin-protein ligase MID2 isoform 1
NM_052817.3 NP_438112.2 probable E3 ubiquitin-protein ligase MID2 isoform 2

MID2 Protein Structure

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (27 - 83)

zf-B_box

zf-B_box: B-box zinc finger (193 - 231)

SPRY

SPRY: SPRY domain (588 - 697)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
Protein Preferred Names Protein Names

probable E3 ubiquitin-protein ligase MID2

RING finger protein 60

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, X-Linked 101

XLID101

Mental Retardation, X-Linked 101

Mrx101

Mental Retardation, X-Linked, Type 101
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
Opitz Gbbb Syndrome

Opitz G/Bbb Syndrome

Opitz Syndrome

Hypertelorism-Hypospadias Syndrome

Hypertelorism With Esophageal Abnormality And Hypospadias

Opitz-Frias Syndrome

Os

Osx

Telecanthus-Hypospadias Syndrome

Opitz Gbbb Syndrome Type I

Opitz Bbbg Syndrome

Hypospadias-Dysphagia Syndrome

Opitz Bbb/G Syndrome

GBBB

Opitz Gbbb Syndrome, X-Linked

Opitz Syndrome, X-Linked

Opitz Gbbb Syndrome, Type I, Formerly

Gbbb1, Formerly

Opitz-G Syndrome, Type I, Formerly

Ogs1, Formerly

Opitz Bbbg Syndrome, Type I, Formerly

Bbbg1, Formerly

Bbb Syndrome

G Syndrome

Gbbb Syndrome

Hypertelorism Hypospadias Syndrome

Hypospadias-Dysphagia, Syndrome

Opitz-G Syndrome, Type 2

Telecanthus With Associated Abnormalities

Hypertelorism With Esophageal Abnormalities And Hypospadias

Hypertelorism-Hypospadias Sydrome

Opitz Bbb Syndrome

Opitz G Syndrome

Hypertelorism-Oesophageal Abnormality-Hypospadias Syndrome

Opitz Gbbb Syndrome 1

GBBB1

Bbbg1

Gggb1

Opitz Bbbg Syndrome Type I

Opitz Gbbb Syndrome X-Linked

Opitz-G Syndrome Type I

Opitz Syndrome X-Linked

Opitz G Syndrome, Type I

Opitz Bbbg Syndrome, Type I
Hypospadias

Hypospadias Familial

Familial Hypospadias
Non-Syndromic X-Linked Intellectual Disability 63

Acsl4-Related Intellectual Disability

Mrx63

Mrx68

X-Linked Mental Retardation 68
Non-Syndromic X-Linked Intellectual Disability 101

Mrx101

X-Linked Mental Retardation 101
Myringitis Bullosa Hemorrhagica

Bullous Myringitis
Non-Syndromic X-Linked Intellectual Disability 30

Mrx30

Mrx47

X-Linked Mental Retardation 30/47

X-Linked Mental Retardation 47

Mental Retardation, X-Linked, Type 30/47
Tetanus Neonatorum

Neonatal Tetanus

NNT

Trismus Neonatorum

Newborn Trismus
Opitz-Kaveggia Syndrome

Fg Syndrome

Fgs1

Fgs

Keller Syndrome

OKS

Fg Syndrome 1

Fg Syndrome Type 1

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Urinary Schistosomiasis

Schistosoma Haematobium Infection

Schistosoma Hematobium Infection

Schistosomiasis Due To Schistosoma Haematobium

Bladder Schistosomiasis

Cystitis With Bilharziasis

Schistosoma Haematobium

Schistosoma Hematobium Infectious Disease

Schistosomiasis Of Bladder

Vesical Schistosomiasis

Schistosomiasis Urinary

Schistosomiasis Haematobia

Genitourinary Bilharziasis

Genitourinary Tract Schistosomiasis

Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis]

Haematochyluria In Schistosomiasis

Infection Due To Schistosoma Matthei
Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08436 MID2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MID2 VGNC VGNC:43224
Mus musculus MID2 MGD MGI:1344333
Macaca mulatta MID2 VGNC VGNC:74722
Rattus norvegicus MID2 RGD RGD:1565674
Bos taurus MID2 VGNC VGNC:106822
Felis catus MID2 VGNC VGNC:68256