SLC35D2 - solute carrier family 35 member D2 Gene

Homo sapiens

Also known as hfrc; HFRC1; SQV7L; UGTrel8

Gene ID: 11046 | Gene type: protein coding

About SLC35D2

Cytogenetic location: 9q22.32 Genomic coordinates (GRCh38): 9:96,313,444-96,383,711 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 9 paralogues. Ubiquitous expression in small intestine (RPKM 17.7), duodenum (RPKM 17.4) and 25 other tissues.

Summary

Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]

SLC35D2 Products(2)

mRNA	Protein	Name
NM_001286990.2	NP_001273919.1	UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter isoform b
NM_007001.3	NP_008932.2	UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter isoform a

SLC35D2 Protein Structure

TPT

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter

SQV7-like protein

Related Diseases

Diseases

Alias

Dicarboxylic Aminoaciduria

Glutamate-Aspartate Transport Defect	Dicarboxylicaminoaciduria
DCBXA	Renal Aminoacidurias

Thiamine-Responsive Megaloblastic Anemia Syndrome

TRMA	Rogers Syndrome
Thiamine-Responsive Myelodysplasia	Thiamine-Responsive Anemia Syndrome
Thiamine Metabolism Dysfunction Syndrome 1	Thmd1
Megaloblastic Anemia, Thiamine-Responsive, With Diabetes Mellitus And Sensorineural Deafness	Thiamine-Responsive Megaloblastic Anemia With Diabetes Mellitus And Sensorineural Deafness
Thiamine Responsive Megaloblastic Anemia Syndrome	Megaloblastic Anemia Thiamine-Responsive With Diabetes Mellitus And Sensorineural Deafness
Thiamine-Responsive Megaloblastic Anemia	Thiamine-Responsive Anaemia Syndrome
Thiamine-Responsive Megaloblastic Anaemia Syndrome	Thiamine-Responsive Megaloblastic Anaemia With Diabetes Mellitus And Sensorineural Deafness
Thiamine-Responsive Megaloblastic Anemia With Diabetes Mellitus And Sensorineural Hearing Loss

Hydranencephaly

Hydroanencephaly

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13202	SLC35D2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLC35D2	VGNC	VGNC:102983
Macaca mulatta	SLC35D2	VGNC	VGNC:77534
Canis familiaris	SLC35D2	VGNC	VGNC:46371
Bos taurus	SLC35D2	VGNC	VGNC:52827
Rattus norvegicus	SLC35D2	RGD	RGD:1309518
Mus musculus	SLC35D2	MGD	MGI:1917734

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