KERA - keratocan Gene

Also Known as KTN; CNA2; SLRR2B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11081

About KERA

Cytogenetic location: 12q21.33 Genomic coordinates (GRCh38): 12:91,050,491-91,058,024 (from NCBI)

This gene has 1 transcript (splice variant), 203 orthologues, 10 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]

KERA Products (1)

mRNA Protein Name
NM_007035.4 NP_008966.1 keratocan precursor

KERA Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (42 - 70)

LRR_8

LRR_8: Leucine rich repeat (75 - 133)

LRR_8

LRR_8: Leucine rich repeat (143 - 204)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

keratocan

  • keratan sulfate proteoglycan keratocan

Related Diseases

Diseases Alias
Cornea Plana 2, Autosomal Recessive

  • CNA2

  • Cornea Plana Congenita, Recessive
Congenital Cornea Plana
Cornea Plana

  • Flat Cornea
Keratoconus

  • Kc

  • Conical Cornea

  • Noninflammatory Corneal Thining

  • Bulging Cornea

  • Cornea Conical

  • Acquired Conus Of Cornea
Cloacogenic Carcinoma

  • Cloacogenic Anal Carcinoma
Macular Dystrophy, Corneal

  • Macular Corneal Dystrophy

  • MCD

  • Corneal Dystrophy, Macular Type

  • Groenouw Type Ii Corneal Dystrophy

  • Fehr Corneal Dystrophy

  • Macular Dystrophy, Corneal Type 1

  • Mcdc1

  • Macular Corneal Dystrophy Type Ii

  • Macular Corneal Dystrophy, Type Ii

  • Macular Corneal Dystrophy, Type I

  • Mcdc1, Formerly

  • Macular Dystrophy, Corneal, 1

  • Macular Corneal Dystrophy Type 1

  • Corneal Dystrophy Groenouw Type Ii

  • Corneal Dystrophy Macular Type

  • Macular Corneal Dystrophy Type I

  • Dystrophy, Macular, Corneal
Stromal Dystrophy
Corneal Ectasia
Corneal Dystrophy, Posterior Amorphous

  • Posterior Amorphous Corneal Dystrophy

  • PACD

  • Chromosome 12q21.33 Deletion Syndrome

  • Posterior Amorphous Stromal Dystrophy
Corneal Dystrophy
Accommodative Esotropia

  • Esotropia With Accommodative Compensation
Exposure Keratitis

  • Exposure Keratoconjunctivitis

  • Lagophthalmic Keratitis
Corneal Dystrophy, Congenital Stromal

  • Congenital Stromal Corneal Dystrophy

  • CSCD

  • Congenital Hereditary Stromal Dystrophy

  • Congenital Hereditary Stromal Dystrophy Of The Cornea

  • Congenital Stromal Dystrophy Of The Cornea

  • Dacs

  • Decorin-Associated Congenital Stromal Corneal Dystrophy

  • Dystrophia Corneae Parenchymatosa Congenita

  • Witschel Dystrophy

  • Dystrophy, Corneal, Stromal, Congenital
Irregular Astigmatism
Corneal Ulcer

  • Cornea Ulcer

  • Ulcerative Keratitis

  • Corneal Ulcer Nos
Corneal Disease

  • Corneal Diseases

  • Corneal Disorders
Corneal Edema

  • Corneal Oedema

  • Infiltrate Of Cornea
Sclerocornea

  • Isolated Congenital Sclerocornea
Bullous Keratopathy

  • Bk - [Bullous Keratopathy]
Corneal Degeneration

  • Degenerative Corneal Opacity
Refractive Error

  • Refractive Errors
Eye Accommodation Disease
Keratopathy
Steroid-Induced Glaucoma

  • Corticosteroid-Induced Glaucoma
Nanophthalmos

  • Nanophthalmia
Keratitis, Hereditary

  • Keratitis

  • Autosomal Dominant Keratitis

  • Hereditary Keratitis

  • Dominantly Inherited Keratitis

  • Keratitis Hereditary

  • KERH
Axenfeld-Rieger Syndrome

  • Axenfeld Syndrome

  • Rieger Syndrome

  • Rieger Anomaly

  • Axenfeld Anomaly

  • Anomaly, Rieger'S

  • Hagedoom Syndrome

  • Rgs - Rieger Syndrome

  • Rieger'S Anomaly

  • Goniodysgenesis Hypodontia

  • Iridogoniodysgenesis With Somatic Anomalies

  • Ars

  • Axenfeld And Rieger Anomaly

  • Axra

  • Axrs

  • Rieger Eye Malformation Sequence
Fuchs' Endothelial Dystrophy

  • Fuchs Endothelial Corneal Dystrophy

  • Fuchs Endothelial Dystrophy

  • Fuchs Dystrophy

  • Fced

  • Fuchs' Corneal Dystrophy

  • Fuchs' Endothelial Corneal Dystrophy

  • Fuchs Atrophy

  • Fuchs Corneal Dystrophy

  • Endoepithelial Corneal Dystrophy

  • Fecd

  • Late Hereditary Endothelial Dystrophy

  • Corneal Dystrophy, Fuchs Endothelial

  • Dystrophy, Corneal, Fuchs Endothelial

  • Corneal Dystrophy, Fuchs' Endothelial, 1
Anterior Segment Dysgenesis

  • Anterior Segment Developmental Anomaly

  • Anterior Segment Mesenchymal Dysgenesis

  • Corneal Opacification And Other Ocular Anomalies

  • Sclerocornea With Other Ocular Anomalies

  • Asmd

  • Asod

  • Anterior Segment Ocular Dysgenesis

  • Foxe3-Related Ocular Disorder

  • Familial Ocular Anterior Segment Mesenchymal Dysgenesis

  • Dysgenesis, Anterior Segment

  • Irido-Corneal Dysgenesis

  • Axenfeld-Rieger Syndrome, Type 3
Aniridia 1

  • Aniridia

  • Congenital Aniridia

  • AN1

  • An

  • Cataract With Late-Onset Corneal Dystrophy

  • Aplasia Of Iris

  • Absent Iris

  • Irideremia

  • Aniridia Ii, Formerly

  • An2, Formerly

  • An2

  • Aniridia Type Ii

  • Aniridia, Type 1

  • An-1

  • Absence Of Iris

  • Agenesis Of Iris

  • Congenital Absence Of Iris

  • Hereditary Aniridia

  • Sporadic Aniridia
Eye Disease

  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-E70193 Keratinase Degrader / Phase 4

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07234 KERA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18482 Kera Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24963 Kera Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KERA VGNC VGNC:42334
Mus musculus KERA MGD MGI:1202398
Rattus norvegicus KERA RGD RGD:1305816
Macaca mulatta KERA VGNC VGNC:108355
Bos taurus KERA VGNC VGNC:30539
Others KERA NCBI