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Cat. No.: HY-E70193

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Keratinase

(Synonyms: KerA)

Keratinase (KerA) is an orally active proteolytic enzyme that specifically degrades keratin, and it is mainly secreted by microorganisms such as bacteria, fungi and actinomycetes. Keratinase degrades keratin via reducing disulfide bond cross-links and cleaving peptide bonds, and it can also degrade infectious prion proteins. Keratinase can improve the nutritional bioavailability of keratin-based feed, and it can also be applied in various fields including depilation, proteolytic cleaning, organic fertilizer precursor preparation, cosmetics, bioenergy production, wastewater decolorization, biomolecule extraction, bioremediation, textile biopretreatment and feed processing.

For research use only. We do not sell to patients.

CAS No.: 37341-53-0

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Keratinase Chemical Structure

CAS No.: 37341-53-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Keratinase is derived from various bacterial and fungal sources, and exhibits stable activity in keratin degradation, prion inactivation, and leather unhairing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Keratinase (0.05% (w/w); p.o.; continuous feeding) significantly increases glycine and β-conglycinin hydrolysis in weaned piglets and improves intestinal health parameters^[2].
Versazyme keratinase (p.o.; continuous feeding) improves growth performance, feed efficiency, and intestinal function in broiler chickens^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Weaned piglets^[2]
Dosage:

0.05% (w/w)
Administration:

p.o.; continuous feeding
Result:

Increased glycine hydrolysis from 11.81% to 94.74%.
Increased β-conglycinin hydrolysis from 24.20% to 88.89%.
Reduced intestinal E. coli count, total aerobic counts, ammonia nitrogen concentration, and branched-chain volatile fatty acid content.
Improved intestinal architecture and ecology.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 37341-53-0
Appearance Solid
Color White to off-white
SMILES

[Keratinase]
Synonyms

KerA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nnolim NE, et al. Microbial Keratinase: Next Generation Green Catalyst and Prospective Applications. Frontiers in microbiology. 2020;11:580164. [Content Brief]

[2]. Thadiyan V, et al. Keratinase and its diverse applications. 3 Biotech. 2025 Jun;15(6):151. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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